Noninvasive and minimally invasive carcinoma ex mixed tumor: A clinicopathologic and ploidy study of 12 patients with major salivary tumors of low (or no?) malignant potential

doi:10.1016/S1079-2104(96)80071-0

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology

Volume 81, Issue 6, June 1996, Pages 655-664

https://doi.org/10.1016/S1079-2104(96)80071-0 Get rights and content

We studied 12 histologically malignant salivary tumors that showed complete encapsulation or only limited microscopic invasion. Most cases were histologically characterized by atypical and mitotically active luminal cells forming dilated, angular, variably sized glands in the subcapsular region, varying proportions of nonluminal tumor cells, and a background of central fibrosed hyalinized stroma. The appearance is that of a low-grade carcinoma. Focal higher grade carcinoma was superimposed on this histologic data in three cases. Neither recurrences nor metastases were seen in 11 of 12 patients after surgical resection with a follow-up of 1.2 to 13 yrs (mean, 4.2 years). Ploidy studies were performed on the paraffin-embedded tissue in 11 cases and yielded results for 7 cases. Aneuploid cell populations were found in five tumors; two had normal diploid populations; and the ploidy results are not predictive of tumor behavior. This type of salivary gland tumor fits diagnostically within the category of noninvasive and minimally invasive carcinoma ex pleomorphic adenoma (also referred to as in situ and low-grade malignant mixed tumors), a class that requires additional awareness and precise recognition as it signifies a good prognosis after surgical resection.

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^*: Presented in part at the International Academy of Pathology, March 1993, New Orleans, LA, and the International Academy of Oral Pathology, July 1994, York, England.

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Noninvasive and minimally invasive carcinoma ex mixed tumor: A clinicopathologic and ploidy study of 12 patients with major salivary tumors of low (or no?) malignant potential*

Malignant mixed tumors of the salivary glands: a review

Pathol Annu

The World Health Organization's histological classification of salivary gland tumors: a commentary on the second edition

Cancer

Carcinoma ex pleomorphic adenoma and malignant mixed tumors: histomorphologic indexes

Arch Otolaryngol

Ultrastructural contributions to the study of morphological differentiation in malignant mixed (pleomorphic) tumors of salivary gland

Head Neck

Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry

J Histochem Cytochem