Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume 1822, Issue 3, March 2012, Pages 361-369
Volume of white matter hyperintensities in healthy adults: Contribution of age, vascular risk factors, and inflammation-related genetic variants☆
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Highlights
► Question: Do vascular risk and inflammation biomarkers/polymorphisms predict WMH? ► WMH volume is associated with age, hypertension, and homocysteine and CRP levels. ► IL-1β-511T homozygotes and CRP-286T carriers have enlarged WMH. ► ApoE ε2 carriers had larger frontal WMH than ε3 homozygotes, and ε4 carriers.
Keywords
Brain
Aging
CRP
Interleukin
Homocysteine
Frontal lobe
ApoE
MTHFR
ACE
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This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease.
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