Archival ReportAge-Related Differences in White Matter Tract Microstructure Are Associated with Cognitive Performance from Childhood to Adulthood
Section snippets
Participants
Two-hundred and ninety-six healthy individuals (52% male) between the ages of 8.1 and 68.1 years (mean 29.6 ± 14.6; median 25.9) were recruited through local advertisements and by word of mouth. Written informed consent was obtained from participants or from a parent or guardian if the participant was a minor; all minors provided assent. Participants had no history of a DSM-IV Axis I major mood or psychotic disorder as assessed by structured diagnostic interview 20, 21. Other exclusion criteria
Age-Related Differences in WM Tract Microstructure
There were no significant correlations between age and the asymmetry indices of the bilateral tracts (FA left – FA right/FA left + FA right) or significant age-by-sex interactions on tract FA for the slope and curvature terms in the Poisson or quadratic models [level of significance set at p < .0028, to correct for the two slope and curvature terms (a and b terms) in each model and for the nine tracts, that is, .050/ (2 * 9)]. Therefore, FA values were combined for males and females and
Discussion
In accordance with our hypothesis and with previous cross-sectional studies 3, 4, 5, significant FA differences were observed between childhood and early adulthood in a projection tract, two interhemispheric tracts and most association tracts. The uncinate fasciculus displayed little age-related FA difference, which is corroborated to some degree by a longitudinal study of healthy individuals aged 5 to 32 years (31). FA of the ATR showed a negative linear correlation with age from childhood to
References (38)
- et al.
Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI
J Magn Reson B
(1996) - et al.
Diffusion tensor imaging of white matter tract evolution over the lifespan
Neuroimage
(2012) - et al.
Fractional anisotropy of water diffusion in cerebral white matter across the lifespan
Neurobiol Aging
(2012) - et al.
Morphometry and connectivity of the fronto-parietal verbal working memory network in development
Neuropsychologia
(2011) - et al.
The development of corpus callosum microstructure and associations with bimanual task performance in healthy adolescents
Neuroimage
(2008) - et al.
Age-related decline in white matter tract integrity and cognitive performance: A DTI tractography and structural equation modeling study
Neurobiol Aging
(2012) - et al.
Age-related slowing of memory retrieval: Contributions of perceptual speed and cerebral white matter integrity
Neurobiol Aging
(2008) - et al.
White matter tracts associated with set-shifting in healthy aging
Neuropsychologia
(2009) - et al.
Testing the white matter retrogenesis hypothesis of cognitive aging
Neurobiol Aging
(2012) - et al.
Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): Initial reliability and validity data
J Am Acad of Child Adolesc Psychiatry
(1997)
The Assessment and Analysis of Handedness: The Edinburgh Inventory
Neuropsychologia
A global optimisation method for robust affine registration of brain images
Med Image Anal
Demyelination increases radial diffusivity in corpus callosum of mouse brain
Neuroimage
Neural substrates of choice selection in adults and adolescents: Development of the ventrolateral prefrontal and anterior cingulate cortices
Neuropsychologia
Cognitive and emotional influences in anterior cingulate cortex
Trends Cogn Sci
Anatomic dissection of the inferior fronto-occipital fasciculus revisited in the lights of brain stimulation data
Cortex
The basis of anisotropic water diffusion in the nervous system–a technical review
NMR Biomed
Life-span changes of the human brain white matter: Diffusion tensor imaging (DTI) and volumetry
Cereb Cortex
White matter development in adolescence: Diffusion tensor imaging and meta-analytic results
Schizophr Bull
Cited by (110)
Socioeconomic Disparities in Hypothalamic-Pituitary-Adrenal Axis Regulation and Prefrontal Cortical Structure
2024, Biological Psychiatry Global Open ScienceAge-related, multivariate associations between white matter microstructure and behavioral performance in three executive function domains
2023, Developmental Cognitive NeuroscienceEarly life stress, sleep disturbances, and depressive symptoms during adolescence: The role of the cingulum bundle
2023, Developmental Cognitive NeuroscienceAltered white matter organization and its correlations with executive functioning among adolescents with epilepsy
2023, European Journal of Paediatric Neurology