Original ArticleSpectrum of Disease and Outcome in Children with Symptomatic Congenital Cytomegalovirus Infection
Section snippets
Methods
The study population consisted of 178 children with symptomatic cCMV enrolled in a longitudinal follow-up study. An additional 9 children were found to have cCMV but were not enrolled in follow-up (7 died and 2 were lost to follow-up). Data on asymptomatic infants from this population have been described in previous published studies.16, 17, 18 Infants were classified as having symptomatic cCMV when they were positive for CMV within the first 3 weeks of life and had any findings suggestive of
Results
Of the 178 children with symptomatic cCMV enrolled in follow-up between January 1980 and January 2002, 78 infants were identified on newborn virologic screening and the remaining 100 infants were referred from other hospitals. The demographic characteristics were compared between screened and referred children, and the results are shown in Table I. Infants in the screened group were more likely to be African American, born prematurely, and born to single mothers and to have received prenatal
Discussion
Studies estimating long-term outcome in children with symptomatic cCMV have reported varying rates of sequelae, from 35% to 100%.2, 3, 4, 5, 15, 23 The findings from the current study demonstrate that among children with confirmed cCMV, the sequelae rates vary significantly based on the clinical presentation at birth and on whether infants were identified by newborn screening or by clinical suspicion. The proportion of children with various newborn clinical findings in the referred group was
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Cited by (0)
Funded in part by the grants from the National Institutes of Health (5-P01-HD-10699 [to W.B., K.F.], 5-R01-DC-02139 [to S.B., K.F.], 5-P01-A1-43681 [to S.B., W.B., K.F], and M01-RR-00032. The authors declare no conflicts of interest.