Original ArticleDiffusion Tensor Imaging for Intracerebral Hemorrhage Outcome Prediction: Comparison Using Data from the Corona Radiata/Internal Capsule and the Cerebral Peduncle
Section snippets
Patients
The study population was comprised of stroke patients with ICH who were admitted to our hospital between January 2010 and March 2011. These patients were transferred to our hospital soon after onset. Typically, these patients underwent conservative treatment such as medication to reduce hypertension and, for some, necessary surgical removal of hematoma. During hospitalization, they also underwent physical therapy, occupational therapy, and speech therapy for a combined daily total of up to 180
Results
Table 1 presents the profiles of 32 patients enrolled in this study. For these patients, rFA values ranged from 0.548 to 1.059 (median 0.848) for the cerebral peduncle and from 0.415 to 1.026 (median 0.732) for the corona radiata/internal capsule. Fig 2 shows typical brain images (CT and DTI-FA) from 5 patients (1, 8, 16, 24, and 32 in Table 1). Despite the variations in size and location of hematoma, DTI-FA brain images transformed into the standard space (Fig 1) were comparable across
Discussion
To develop a clinical useful method for motor outcome prediction, we have been applying newly developed MRI–DTI technology. Applying this technique, we investigated whether neural degeneration (rFA value) and in particular corticospinal tracts better predicts motor outcome. We found that FA values from the cerebral peduncle better predict motor outcome than values from the corona radiata/internal capsule.
Conclusion
Using computer-automated methodology, we successfully transformed the brain images of individual patients to the standard space. These DTI-FA images were comparable across patients, suggesting clinical applicability of this methodology. Using templates for corticospinal tracts located in the standard space, we compared the predictive accuracy of data from the corona radiata/internal capsule and the cerebral peduncle. Our analyses showed that FA values recorded in the cerebral peduncle better
Acknowledgment
The authors thank FMRIB Image Analysis Group, Oxford University for the FSL analysis software.
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Supported by the Medical Research Fund of the Hyogo Medical Association (MRF-H-06-10).