Clinical StudyThree-Dimensional Quantitative Color-Coding Analysis of Hepatic Arterial Flow Change during Chemoembolization of Hepatocellular Carcinoma
Section snippets
Patient Selection
This prospective, single-institution study was approved by the institutional review board. Consecutive patients with HCC who underwent conventional transcatheter arterial chemoembolization between December 2015 and March 2017 were enrolled in this study. All patients provided written informed consent. HCC was diagnosed either through biopsy or by established diagnostic imaging criteria using 4-phase computed tomography (CT) or magnetic resonance imaging. Patients were selected for transcatheter
Results
BATs of the proximal lobar arteries and the segmental artery that received embolization were calibrated using the BAT of the PHA as a reference point. BATs before and after chemoembolization of the segmental artery that received embolization were 0.47 second (IQR, 0.31–0.70 s) and 1.04 seconds (IQR, 0.78–2.01 s; P < .001), respectively. BATs before and after chemoembolization of the proximal left lobar artery were 0.35 second (IQR, 0.11–0.55 s) and 0.13 second (IQR, 0.05–0.32 s; P = .25). BATs
Discussion
The results revealed that BAT can objectively quantify the sluggish arterial flow of a segmental artery that has received embolization in 3D QCA after transcatheter arterial chemoembolization. In contrast to 2D QCA 7, 8, the seed point can be placed precisely in the vessel of interest by viewing through different projection angles in 3D QCA. Consequently, the output data of 3D QCA was free from contamination caused by overlapping vasculature or tumors, which are frequently encountered in 2D
Acknowledgments
This research was supported by Taipei Veterans General Hospital and Siemens Healthcare (grant no. T1100200).
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F.C.-H.W., S.G., and M.K. are paid employees of Siemens Healthcare (Erlangen, Germany). None of the other authors have identified a conflict of interest.