Elsevier

Neurologic Clinics

Volume 28, Issue 1, February 2010, Pages 253-275
Neurologic Clinics

Neurologic Presentations of AIDS

https://doi.org/10.1016/j.ncl.2009.09.018Get rights and content

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HIV-1–associated syndromes in primary infection

Acute HIV infection is the period from initial infection to complete seroconversion. During this time 40% to 90% of individuals describe physical symptoms, similar to influenza, or mononucleosis. The most common features include a short period of fever, lymphadenopathy, night sweats, headache, or rash.8, 9 Early CNS infection is usually asymptomatic, but cerebrospinal fluid (CSF)10 and imaging studies11 can detect abnormalities even during the “asymptomatic” period that presage later neurologic

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References (191)

  • S. Letendre et al.

    Validation of the CNS penetration-effectiveness rank for quantifying antiretroviral penetration into the central nervous system

    Arch Neurol

    (2008)
  • J.E. Clements et al.

    The central nervous system is a viral reservoir in simian immunodeficiency virus-infected macaques on combined antiretroviral therapy: a model for human immunodeficiency virus patients on highly active antiretroviral therapy

    J Neurovirol

    (2005)
  • B.J. Brew et al.

    Neurodegeneration and ageing in the HAART era

    J Neuroimmune Pharmacol

    (2009)
  • S.T. Huang et al.

    Acute human immunodeficiency virus infection

    J Microbiol Immunol Infect

    (2005)
  • R. Fox et al.

    Clinical manifestations of acute infection with human immunodeficiency virus in a cohort of gay men

    AIDS

    (1987)
  • L. Resnick et al.

    Early penetration of the blood-brain-barrier by HIV

    Neurology

    (1988)
  • E. Tarasow et al.

    Cerebral MR spectroscopy in neurologically asymptomatic HIV-infected patients

    Acta Radiol

    (2003)
  • C.G. Krasner et al.

    Bilateral Bell's palsy and aseptic meningitis in a patient with acute human immunodeficiency virus seroconversion

    West J Med

    (1993)
  • P. Serrano et al.

    Bilateral Bell palsy and acute HIV type 1 infection: report of 2 cases and review

    Clin Infect Dis

    (2007)
  • H. Hollander et al.

    Neurologic abnormalities and recovery of human immunodeficiency virus from cerebrospinal fluid

    Ann Intern Med

    (1987)
  • K.A. Wendel et al.

    Acute meningoencephalitis in chronic human immunodeficiency virus (HIV) infection: putative central nervous system escape of HIV replication

    Clin Infect Dis

    (2003)
  • M.G. Worthington et al.

    Aseptic meningitis and acute HIV syndrome after interruption of antiretroviral therapy: implications for structured treatment interruptions

    AIDS

    (2003)
  • A. Antinori et al.

    Updated research nosology for HIV-associated neurocognitive disorders

    Neurology

    (2007)
  • S.P. Woods et al.

    Cognitive neuropsychology of HIV-associated neurocognitive disorders

    Neuropsychol Rev

    (2009)
  • M. Reger et al.

    A meta-analysis of the neuropsychological sequelae of HIV infection

    J Int Neuropsychol Soc

    (2002)
  • S. Tross et al.

    Neuropsychological characterization of the AIDS dementia complex: a preliminary report

    AIDS

    (1988)
  • D.C. Delis et al.

    Do patients with HIV-associated minor cognitive/motor disorder exhibit a ‘subcortical’ memory profile? Evidence using the California verbal learning test

    Assessment

    (1995)
  • B. Pillon et al.

    Are explicit memory disorders of progressive supranuclear palsy related to damage to striatofrontal circuits? Comparison with Alzheimer's, Parkinson's, and Huntington's diseases

    Neurology

    (1994)
  • B.A. Navia et al.

    The AIDS dementia complex: II. Neuropathology

    Ann Neurol

    (1986)
  • S. Tisch et al.

    Parkinsonism in HIV-infected patients on highly active antiretroviral therapy

    Neurology

    (2009)
  • S.A. Castellon et al.

    Neuropsychiatric disturbance is associated with executive dysfunction in HIV-1 infection

    J Int Neuropsychol Soc

    (2000)
  • M.A. Cole et al.

    Relationship between psychiatric status and frontal-subcortical systems in HIV-infected individuals

    J Int Neuropsychol Soc

    (2007)
  • J.L. Ayuso Mateos et al.

    Drug treatment of HIV associated neuropsychiatric syndromes

    Neurologia

    (2000)
  • E.G. Bing et al.

    Psychiatric disorders and drug use among human immunodeficiency virus-infected adults in the United States

    Arch Gen Psychiatry

    (2001)
  • C.G. Lyketsos et al.

    AIDS mania

    J Neuropsychiatry Clin Neurosci

    (1997)
  • E. Nakimuli-Mpungu et al.

    Primary mania versus HIV-related secondary mania in Uganda

    Am J Psychiatry

    (2006)
  • P. Portegies et al.

    Presentation and course of AIDS dementia complex: 10 years of follow-up in Amsterdam, The Netherlands

    AIDS

    (1993)
  • J.C. McArthur et al.

    Dementia in AIDS patients: incidence and risk factors. Multicenter AIDS Cohort Study

    Neurology

    (1993)
  • R.J. Ellis et al.

    Progression to neuropsychological impairment in human immunodeficiency virus infection predicted by elevated cerebrospinal fluid levels of human immunodeficiency virus RNA

    Arch Neurol

    (2002)
  • Y. Stern et al.

    Factors associated with incident human immunodeficiency virus—dementia

    Arch Neurol

    (2001)
  • B.A. Navia et al.

    The AIDS dementia complex: I. Clinical features

    Ann Neurol

    (1986)
  • W.D. Snider et al.

    Neurological complications of acquired immune deficiency syndrome: analysis of 50 patients

    Ann Neurol

    (1983)
  • B.J. Brew

    Evidence for a change in AIDS dementia complex in the era of highly active antiretroviral therapy and the possibility of new forms of AIDS dementia complex

    AIDS

    (2004)
  • T. Ernst et al.

    Effect of aging on brain metabolism in antiretroviral-naive HIV patients

    AIDS

    (2004)
  • G.J. Dore et al.

    Changes to AIDS dementia complex in the era of highly active antiretroviral therapy

    AIDS

    (1999)
  • J.J. Sevigny et al.

    Evaluation of HIV RNA and markers of immune activation as predictors of HIV-associated dementia

    Neurology

    (2004)
  • L.A. Cysique et al.

    Undetectable cerebrospinal fluid HIV RNA and beta-2 microglobulin do not indicate inactive AIDS dementia complex in highly active antiretroviral therapy-treated patients

    J Acquir Immune Defic Syndr

    (2005)
  • M. Descamps et al.

    Magnetic resonance imaging and spectroscopy of the brain in HIV disease

    J HIV Ther

    (2008)
  • R.H. Paul et al.

    Relative sensitivity of magnetic resonance spectroscopy and quantitative magnetic resonance imaging to cognitive function among nondemented individuals infected with HIV

    J Int Neuropsychol Soc

    (2008)
  • R.H. Paul et al.

    Apathy is associated with volume of the nucleus accumbens in patients infected with HIV

    J Neuropsychiatry Clin Neurosci

    (2005)

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    This work was supported by Grants NS38841, U01MH083500, and R03DA026099, from the National Institutes of Health.

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