Elsevier

Neuroscience Research

Volume 66, Issue 4, April 2010, Pages 406-411
Neuroscience Research

Rapid communication
Transient decrease in cerebral motor pathway fractional anisotropy after focal ischemic stroke in monkey

https://doi.org/10.1016/j.neures.2010.01.001Get rights and content

Abstract

In this study, diffusion tensor MRI was used to examine the restoration of the cerebral white matter of macaque monkeys after unilateral cerebral multiple microinfarctions. Post-stroke, the monkeys showed deficits in several neurological functions, including motor functions, but most of the deficits resolved within 6 weeks. Very interestingly, the fractional anisotropy (a value determined by diffusion tensor MRI), of the monkeys’ affected motor pathways dropped transiently, indicating a damage in the neural tracts. However, it returned to normal levels within 6 weeks after the stroke, concomitant with the gradual recovery of motor functions at subacute phase.

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Acknowledgements

This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (T.H.), and from the Ministry of Health, Labor, and Welfare of Japan (Y.Y.). We thank Naoyuki Saito, Yuko Katakai, Hiromi Ogawa, and Hayato Narita of the Tsukuba Primate Research Center for their support and excellent animal care, Drs. Shigeki Aoki, Osamu Abe, and Yoshitaka Masutani for MRI analysis, Dr. Nobutaka Kawahara for the development of the

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    A small number of nonhuman primate models of ischemia and stroke currently exist and have provided a wealth of knowledge about ischemic injury, recovery of function, and cortical reorganization. Several groups, using cynomolgus monkeys, have investigated the efficacy of various therapeutic interventions after ischemic damage to several regions of cortex (Chin et al., 2010; Li et al., 2010; Sato et al., 2009). While providing valuable insight into the effectiveness of these treatments, the animals in these studies did not complete extensive motor testing and there was considerable variability in lesion placement.

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These two authors equally contributed to this study.

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