Diffusivity and diffusion anisotropy of cerebellar peduncles in cases of spinocerebellar degenerative disease
Section snippets
Introduction/purpose
In patients with spinocerebellar degenerative disease, loss of volume in cerebellar peduncles is determined by pathologic or radiologic methods (Burk et al., 1996, Murata et al., 1998a, Murata et al., 1998b, Tokumaru et al., 2003). Patterns of cerebellar peduncle impairment have been shown to differ based on variations in spinocerebellar degenerative disease (Burk et al., 1996, Murata et al., 1998a, Murata et al., 1998b, Tokumaru et al., 2003). MRI is useful for noninvasively evaluating these
Materials and methods
The subjects were 15 cases (8 men, 7 women; age range 26 to 69 years) with spinocerebellar degenerative disease, including 7 (3 men, 4 women; age range 27 to 56 years) with dentatorubro-pallidoluysian atrophy (DRPLA), 4 (1 man, 3 women; age range 59 to 68 years) with multiple system atrophy, cerebellar type (MSA-C) and 4 (4 men; age range 26 to 69 years) with late cerebellar cortical atrophy (LCCA). Duration of the disease, major complaint of the patients and the means for diagnosis are
Results
Examples of the tractography of DRPLA group, MSA-C group, LCCA group and control group are shown in Fig. 2. In Fig. 3, we show FA and ADC values of the three cerebellar peduncles for the four (DRPLA, MSA-C, LCCA and control) groups by tract based method. While, Fig. 4 shows FA and ADC values of cerebellar peduncles of four groups by ROI method. Numbers of voxels included in the three cerebellar peduncles are shown in Fig. 5.
FA values of SCP by using tractography based measurement showed
Discussion
Diffusion tensor imaging is a powerful tool for evaluating disorders of neuronal degeneration or neuronal loss in that it reflects loss of fiber as increased diffusivity and decreased diffusion anisotropy (Yoshiura et al., 2002, Shimono et al., 2003, Abe et al., 2004a, Abe et al., 2004b, Reading et al., 2005, Shiga et al., 2005, Taoka et al., 2005). There are several methods for measuring diffusivity and diffusion anisotropy on diffusion tensor imaging, including the “region of interest (ROI)”
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