PET in head and neck RTPrediction of prognosis using standardized uptake value of 2-[18F] fluoro-2-deoxy-d-glucose positron emission tomography for nasopharyngeal carcinomas
Section snippets
Patients
We retrospectively analyzed the medical records of 41 patients with non-disseminated NPC who were referred for definitive RT to the Department of Radiation Oncology, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea, between November 2001 and December 2003. Eligible patients were those with biopsy-proven SCC, including those with poorly differentiated and undifferentiated carcinomas, who had received definitive RT combined with concurrent chemotherapy. In addition,
Demographic data
Patient characteristics are summarized in Table 1. The median patient age was 48 years (range, 17 to 78 years). Of the 41 patients, 35 were men and 6 were women, all of whom underwent curative RT; 3 for stage I, 8 for stage II, 18 for stage III and 12 for stage IV tumors. Histologically, 1 tumor was WHO type I, 10 were WHO type II, 25 were WHO type III, and 5 were unspecified. Of the 41 patients, 36 (88%) received cisplatin based CCRT. Based on WHO criteria, all patients showed a clinically
Discussion
Although NPC is highly sensitive to RT or chemotherapy, the 3-year progression free survival rate for patients treated with CCRT was found to be 69% [3]. Improving treatment outcomes requires the identification of factors predictive of better prognosis. Among the prognostic factors of NPC are stage group, neck node involvement, intracranial extension, cranial nerve involvement and parapharyngeal involvement, none of which could predict outcome. The identification of additional prognostic
Acknowledgments
Poster presented at the 3rd annual meeting of The Academy of Molecular Imaging, Orlando, FL, USA, March 18-22, 2005. This study was supported by a Grant (02-PJ1-PG3-20802-0009) from the Ministry of Health and Welfare, Republic of Korea.
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