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The Prognostic Role of Vessel Productive Changes and Vessel Density in Oligodendroglioma

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Abstract

The recognition of the anaplastic variant of oligodendroglioma is difficult, since it is not easy to identify histological prognostic factors. Among the latter, vascular productive changes have been inconsistently put in relation with survival. In 95 cases of operated oligodendrogliomas, endothelial cell hyperplasia, microvascular proliferations and capillary density were studied by histological and immunohistochemical methods. Capillary density was evaluated on CD31-stained sections by a grid of 100 squares placed in the ocular of the microscope. Statistical analysis was performed in order to compare these parameters with survival. A nodular growth pattern was observed more frequently among tumor grades 3–4 than among tumor grades 1–2. Endothelial cell hyperplasia was more frequent in nodular growth pattern, but it did not correlate with survival. The highest capillary density was found in nodular growth pattern, but it did not correlate with survival as well. Microvascular proliferations correlated with survival only in univariate, but not in multivariate analysis. Age, extent of surgical removal, year of surgery, post-operative Karnofsky score and MIB-1 LI remained associated with survival, as observed in a previous study.

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References

  1. Cairncross JG, Macdonald DR: Successful chemotherapy for recurrent malignant oligodendroglioma. Ann Neurol 23: 360-364, 1988

    Google Scholar 

  2. Glass J, Hochberg FH, Gruber ML, Louis DN, Smith D, Rattner B: The treatment of oligodendrogliomas and mixed oligoendroglioma-astrocytomas with PCV chemotherapy. J Neurosurg 76: 741-745, 1992

    Google Scholar 

  3. Kyritis AP, Yung WKA, Bruner J, Gleason MJ, Levin VA: The treatment of anaplastic oligodendrogliomas and mixed gliomas. Neurosurgery 32: 365-371, 1993

    Google Scholar 

  4. Kleihues P, Burger PC, Scheithauer BW: WHO.Histological Typing of Tumours of the Central Nervous System. 2nd edn., 1993 Springer, Berlin, Heidelberg, New York

    Google Scholar 

  5. SmithMT, Ludwig CL, Godfrey AD, Armbrustmacher VW: Grading of oligodendrogliomas. Cancer 52: 2107-2114, 1983

    Google Scholar 

  6. Kros JM, Pieterman H, van Eden CG, Avezaat CJJ: Oligodendroglioma: the Rotterdam-Dijkzigt experience. Neurosurgery 34: 959-966, 1994

    Google Scholar 

  7. Kros JM, Hop WCJ, Godschalk JCJ, Krishnadath KK: Prognostic value of the proliferation-related antigen Ki-67 in oligodendrogliomas. Cancer 78: 1107-1113, 1996

    Google Scholar 

  8. Shaw EG, Scheithauer BW, O'Fallon JR, Tazelaar HD, Davis DH: Oligodendrogliomas: the Mayo Clinic experience. J Neurosurg 76: 428-434, 1992

    Google Scholar 

  9. Burger PC, Rawlings CE, Cox EB, Mc Lendon RE, Schold SC, Bullard DE: Clinicopathologic correlations in the oligodendroglioma. Cancer 59: 1345-1352, 1987

    Google Scholar 

  10. Mørk SJ, Lindergaard K-F, Halvorsen TB, Lehmann EH, Solgaard T, Hatlevoll R, Harvel S, Ganz J: Oligodendroglioma: incidence and biological behaviour in a defined population. J Neurosurg 63: 881-889, 1985

    Google Scholar 

  11. Celli P, Nofrone I, Palma L, Cantore G, Fortuna A: Cerebral oligodendroglioma: prognostic factors and life history. Neurosurgery 35: 1018-1035, 1994

    Google Scholar 

  12. Coons SW, Johnson PC: MIB-1/Ki-67 labeling index predicts patient survival for oligodendroglial tumors. J Neuropathol Exp Neurol 24: 9-12, 1995

    Google Scholar 

  13. Heegard S, Sommer HM, Broholm H, Broendstrup O: Proliferating cell nuclear antigen and Ki-67 immunohistochemistry of oligodendrogliomas with special reference to prognosis. Cancer 76: 1809-1813, 1995

    Google Scholar 

  14. Coons SW, Johnson P, Pearl DK: The prognostic significance of Ki-67 labeling indices for oligodendrogliomas. Neurosurgery 41: 878-884, 1997

    Google Scholar 

  15. Schiffer D, Dutto A, Cavalla P, Bosone I, Chiò A, Villani R, Bellotti C: Prognostic factors in oligodendroglioma. Can J Neurol Sci 24: 313-319, 1997

    Google Scholar 

  16. Daumas-Duport C, Scheithauer B, O'Fallon J, Kelly P: Grading of astrocytomas: a simple and reproducible grading method. Cancer 62: 2152-2165, 1988

    Google Scholar 

  17. Daumas-Duport C, Varlet P, Tucker ML, Beuvon F, Cervera P, Chodkiewicz JP: Oligodendrogliomas. Part I: patterns of growth, histological diagnosis, clinical and imaging correlations: a study of 153 cases. J Neuro-Oncol 34: 37-59, 1997

    Google Scholar 

  18. Daumas-Duport C, Tucker ML, Kolles H, Cervera P, Beuvon F, Varlet P, Udo N, Koziak M, Chodkiewicz JP: Oligodendrogliomas. Part II: a new grading system based on morphological and imaging criteria. J Neuro-Oncol 34: 61-78, 1997

    Google Scholar 

  19. Mørk SJ, Halvorsen TB, Lindergaard K-F, Eide GE: Oligodendroglioma. Histologic evaluation and prognosis. J Neuropathol Exp Neurol 45: 65-78, 1986

    Google Scholar 

  20. Weidner N, Semple JP, Welch WR, Folkman J: Tumor angiogenesis and metastasis - correlation in invasive breast carcinoma. N Engl J Med 324: 1-8, 1991

    Google Scholar 

  21. FisherVW, Siddiqi A, Yusufaly Y: Altered angioarchitecture in selected areas of brains with Alzheimer's disease. Acta Neuropathol 79: 672-679, 1990

    Google Scholar 

  22. Kaplan EL, Meier P: Non-parametric estimation from incomplete observation. JAmStat Assoc 53: 457-481, 1958

    Google Scholar 

  23. Segal MR: Regression trees for censored data. Biometrics 44: 35-47, 1988

    Google Scholar 

  24. Peto R, PikeMG, Armitage P, BreslowNE, Cox DR, Howard SV, Mantel N, Mc Peterson K, Peto J, Smith PG: Design and analysis of randomized clinical trials requiring prolonged observation of each patient: analysis and examples. Br J Cancer 35: 1-39, 1977

    Google Scholar 

  25. Cox DR: Regression models and life tables. J R Stat Soc B34: 187-220, 1972

    Google Scholar 

  26. Schiffer D, Dutto A, Bosone I, Di Vito N: Patterns of neo-vascularization in astrocytic gliomas (submitted for publication)

  27. Leighton C, Fisher B, Bauman G, Depiero S, Stitt L, Macdonald D, Cairncross G: Supratentorial low-grade gliomas in adults: an analysis of prognostic factors and timing of radiation. J Clin Oncol 15: 1294-1301, 1977

    Google Scholar 

  28. Weir B, Elvidge AR: Oligodendrogliomas: an analysis of 60 cases. J Neurosurg 29: 500-505, 1968

    Google Scholar 

  29. Schiffer D, Cavalla P, Pilkington J: Proliferative properties of malignant brain tumors. In: Mikkelsen T, Bjerkvig R, Laerum OD, Rosemblum ML (eds) Brain Tumors Invasion: Biological, Clinical & Therapeutical Considerations. John Wiley-Liss Inc., New York, 1998, pp 161-184

    Google Scholar 

  30. Peterson K, Cairncross JG: Oligodendrogliomas. Brain tumors in adults 13: 861-873, 1995

    Google Scholar 

  31. Kernohan JW, Mabon RF, Svien HJ, Adson AW: A simplified classification of the gliomas. Proc Staff Meet Mayo Clinic 24: 71-75, 1949

    Google Scholar 

  32. Schiffer D, Chiò A, Giordana MT, Mauro A, Migheli A, Vigliani MC: The vascular response to tumor infiltration in malignant gliomas. Morphometric and reconstruction study. Acta Neuropathol 77: 369-378, 1989

    Google Scholar 

  33. Haddad SF, Steven AM, Schelper RL, Goeken JA: Vascular smooth muscle hyperplasia underlies the formation of glomeruloid vascular structures of glioblastoma multiforme. J Neuropathol Exp Neurol 51: 488-492, 1992

    Google Scholar 

  34. Wesseling P, Schlingemann RO, Rietveld FJR, Link M, Burger PC, Ruiter DJ: Early and extensive contribution of pericytes/vascular smooth muscle cells to microvascular proliferation in glioblastoma multiforme: an immuno-light and immuno-electron microscopic study. J Neuropathol Exp Neurol 54: 304-310, 1995

    Google Scholar 

  35. Wesseling P, Ruiter DJ, Burger PC: Angiogenesis in brain tumors; pathobiological and clinical aspects. J Neuro-Oncol 32: 253-265, 1997

    Google Scholar 

  36. Plate KH, Breier G, Weich HA, Mennel HD, Risau W: Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vitro regulatory mechanisms. Int J Cancer 59: 520-529, 1994

    Google Scholar 

  37. Pietsch T, Valter MM, Wolf HK, von Deimling A, Huang HJ, Cavenee WK, Wiestler OD: Expression and distribution of vascular endothelial growth factor protein in human brain tumors. Acta Neuropathol 93: 109-117, 1997

    Google Scholar 

  38. Christov C, Adle-Biassette H, Le Guerinel C, Natchev S, Gherardi RK: Immunohistochemical detection of vascular endothelial growth factor (VEGF) in the vasculature of oligodendrogliomas. Neuropathol Appl Neurobiol 24: 29-35, 1998

    Google Scholar 

  39. Bosari S, Lee AKC, DeLellis RA, Wiley BD, Heatley GJ, Silverman ML: Microvessel quantitation and prognosis in invasive breast carcinoma. Hum Pathol 23: 755-761, 1992

    Google Scholar 

  40. Macchiarini P, Fontanini G, Hardin MJ, Squartini F, Angeletti CA: Relation of neovascularization to metastasis of non-small-cell lung cancer. Lancet 340: 145-146, 1992

    Google Scholar 

  41. Leon SP, Folkerth RD, Black PM: Microvessel density is a prognostic indicator for patients with astroglial brain tumors. Cancer 77: 362-372, 1996

    Google Scholar 

  42. Assimakopoulou M, Sotiropoulou-Bonikou G, Maraziotis T, Papadakis N, Varakis I: Microvessel density in brain tumors. Anticancer Res 17: 4747-4754, 1997

    Google Scholar 

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Authors and Affiliations

  1. Department of Neuroscience, Division of Neurology, University of Turin, Turin, Italy

    Davide Schiffer, Ivana Bosone, Anna Dutto, Nicoletta Di Vito & Adriano Chiò

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  1. Davide Schiffer
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  2. Ivana Bosone
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  3. Anna Dutto
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  4. Nicoletta Di Vito
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  5. Adriano Chiò
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Schiffer, D., Bosone, I., Dutto, A. et al. The Prognostic Role of Vessel Productive Changes and Vessel Density in Oligodendroglioma. J Neurooncol 44, 99–107 (1999). https://doi.org/10.1023/A:1006206920822

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