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Vascular Endothelial Growth Factor (VEGF) in Astrocytic Gliomas – A Prognostic Factor?

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Abstract

Survival in astrocytic gliomas is closely related to WHO tumor grade. Within one tumor grade, especially in grade II and III tumors, the clinical course is variable and can hardly be predicted by histological criteria. Neovascularization is a neuropathological hallmark in high grade gliomas and angiogenic factors may play an important role in malignant tumor progression. Therefore, 162 primary astrocytic gliomas (57 astrocytomas WHO grade II, 27 astrocytomas WHO grade III and 78 glioblastomas WHO grade IV) were investigated immunohistochemically for expression of vascular endothelial growth factor (VEGF), which is considered to represent the main angiogenic factor in astrocytic gliomas. Clinical data known to influence prognosis were documented. VEGF expression was found in 21 of 57 astrocytomas WHO grade II (36.8%), in 18 of 27 astrocytomas WHO grade III (66.7%) and in 50 of 78 glioblastomas (64.1%). A strong correlation between VEGF expression and survival was found within the whole study group, however, within one tumor grade no such correlation was obvious. In a multifactorial analysis VEGF expression was not found to be an independent prognostic factor in astrocytic gliomas.

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Authors and Affiliations

  1. Department of Neurology, University of Bonn, Medical Center, Bonn, Germany

    Randi D. Oehring, Melitta Miletic & Uwe Schlegel

  2. Department of Neuropathology, University of Bonn, Medical Center, Bonn, Germany

    Markus M. Valter & Torsten Pietsch

  3. Department of Neurosurgery, University of Bonn, Medical Center, Bonn, Germany

    Jürgen Neumann

  4. Department of Biostatistics, University of Bonn, Medical Center, Bonn, Germany

    Rolf Fimmers

Authors
  1. Randi D. Oehring
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  2. Melitta Miletic
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  3. Markus M. Valter
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  4. Torsten Pietsch
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  5. Jürgen Neumann
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  6. Rolf Fimmers
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  7. Uwe Schlegel
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Oehring, R.D., Miletic, M., Valter, M.M. et al. Vascular Endothelial Growth Factor (VEGF) in Astrocytic Gliomas – A Prognostic Factor?. J Neurooncol 45, 117–125 (1999). https://doi.org/10.1023/A:1006333005563

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  • DOI: https://doi.org/10.1023/A:1006333005563

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