Abstract
1. The aim of the present study was to reveal the effect of transient forebrain ischemia on the regional and temporal changes in the permeability of the blood-brain barrier (BBB) permeability for sodium fluorescein (MW: 376 Da) and Evan's blue-labeled albumin (MW: 67 kDa) in stroke-prone spontaneously hypertensive rats (SHRSP).
2. BBB permeability was significantly higher in the brain regions of 16-week-old control SHRSP than those in age-matched normotensive Wistar-Kyoto rats.
3. Transient forebrain ischemia evoked by 10-min bilateral carotid occlusion increased the permeability of the BBB for albumin, but not for sodium fluorescein, after 6 and 24 h of reperfusion in brain regions of SHRSP.
4. Extravasation of serum macromolecules may contribute to neuronal loss and development of hypertensive encephalopathy in SHRSP.
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Ábrahám, C.S., Harada, N., Deli, M.A. et al. Transient Forebrain Ischemia Increases the Blood-Brain Barrier Permeability for Albumin in Stroke-Prone Spontaneously Hypertensive Rats. Cell Mol Neurobiol 22, 455–462 (2002). https://doi.org/10.1023/A:1021067822435
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DOI: https://doi.org/10.1023/A:1021067822435