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  • Perinatal/Neonatal Case Presentation
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Perinatal/Neonatal Case Presentation

Persistent cerebral blood flow by transcranial Doppler ultrasonography in an asphyxiated newborn meeting brain death diagnosis: case report and review of the literature

Abstract

We want to illustrate the difficulty of establishing a brain death diagnosis in newborn children and how an easy and useful tool, the transcranial Doppler ultrasonography, can leave an unexpected result that complicates the process despite the rest of the diagnostic tests. We describe a 36-week gestation newborn male who was diagnosed of brain death after asphyxiated and offered for donation. After initial stabilization at admission, we established brain death diagnosis by checking and meeting every criterion. The donation process was complicated because of persistent blood flow on transcranial Doppler ultrasonography. Transcranial Doppler ultrasonography is a very useful method to assess cerebral blood flow. However, caution and individualization are needed when interpreting this complementary exam, especially in highly conflictive situations like brain death diagnosis.

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References

  1. Boletín oficial del estado. Real Decreto 2070/1999, de 30 de diciembre, por el que se regulan las actividades de obtención y utilización clínica de órganos humanos y la coordinación territorial en materia de donación y trasplante de órganos y tejidos. BOE 3/2000 de 4-1-2000, pp 179–90.

  2. Haupt WF, Rudolf J . European brain death codes: a comparison of national guidelines. J Neurol 1999; 246: 432–437.

    Article  CAS  PubMed  Google Scholar 

  3. Monteiro LM, Bollen CW, van Huffelen AC, Ackerstaff RG, Jansen NJ, van Vught AJ . Transcranial Doppler ultrasonography to confirm brain death: a meta-analysis. Intensive Care Med 2006; 32: 1937–1944.

    Article  PubMed  Google Scholar 

  4. Wijdicks EFM . The diagnosis of brain death. N Engl J Med. 2001; 344: 1215–1221.

    Article  CAS  PubMed  Google Scholar 

  5. Ashwal S, Serna-Fonseca T . Brain death in infants and children. Crit Care Nurse 2006; 26: 117–118.

    PubMed  Google Scholar 

  6. Shemie D. . Brain death In: Wheeler DS et al. (eds). Resuscitation and Stabilization of the Critically Ill Child. Springer-Verlag: London Limited, 2009, pp 141–150.

    Google Scholar 

  7. Segura T, Calleja S, Irimia P, Tembl JI . Recommendations for the use of transcranial Doppler ultrasonography to determine the existence of cerebral circulatory arrest as diagnostic support for brain death. Rev Neurosci 2009; 20: 251–259.

    Article  PubMed  Google Scholar 

  8. Ducrocq X, Hassler W, Moritake K, Newell D, Von Reutern GM, Shiogai T et al. Consensus opinion on diagnosis of cerebral circulatory arrest using Doppler-sonography. Task Force Group on cerebral death of the Neurosonology Research Group of the World Federation of Neurology. J Neurol Sci 1998; 159: 145–150.

    Article  CAS  PubMed  Google Scholar 

  9. Hadani M, Gruk B, Ram Z, Knoller N, Spiegelman R, Segal E . Application of transcranial Doppler ultrasonography for the diagnosis of brain death. Intensive Care Med 1999; 25: 98–101.

    Article  Google Scholar 

  10. De Freitas GR, Andre C . Sensitivity of transcranial Doppler for confirming brain death: a prospective study of 270 cases. Acta Neurol Scand 2006; 113: 426–432.

    Article  CAS  PubMed  Google Scholar 

  11. Dosemeci L, Dora B, Yilmaz M, Cengiz M, Balkan S, Ramazanoglu A . Utility of transcranial doppler ultrasonography for confirmatory diagnosis of brain death: two sides of the coin. Transplantation 2004; 77: 71–75.

    Article  PubMed  Google Scholar 

  12. Vicenzini E, Pulitano P, Cicchetti R, Randi F, Papov P, Spadetta G et al. Transcranial Doppler for brain death in infants: the role of the fontanelles. Eur Neurol 2010; 63: 164–169.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to D Mata-Zubillaga.

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Mata-Zubillaga, D., Oulego-Erroz, I. Persistent cerebral blood flow by transcranial Doppler ultrasonography in an asphyxiated newborn meeting brain death diagnosis: case report and review of the literature. J Perinatol 32, 473–475 (2012). https://doi.org/10.1038/jp.2011.147

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