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Accuracy of the Bayley-II mental development index at 2 years as a predictor of cognitive impairment at school age among children born extremely preterm

Journal of Perinatology volume 38, pages 908–916 (2018)Cite this article

Subjects

Abstract

Objective

To describe the accuracy of the Bayley Scales of Infant Development-Second Edition (BSID-II) Mental Development Index (MDI) at 2 years of age for prediction of cognitive function at school age of children born extremely preterm.

Design

Study participants were enrolled in the Extremely Low Gestational Age Newborn Study between 2002 and 2004. Two-thirds of surviving children (n = 795) were assessed at 2 years with the BSID-II and at 10 years with an intelligence quotient (IQ) test. We computed test characteristics for a low MDI (<70), including predictive value positive.

Results

Almost two-thirds of children with a low MDI had a normal IQ (≥ 70) at 10 years. Concordance between MDI and IQ was highest among children with major motor and/or sensory impairment, and when MDI was adjusted for gestational age.

Conclusion

Most children born extremely preterm with low BSID-II MDI at 2 years have normal intelligence at school age.

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Acknowledgements

This study was supported by the National Institute of Neurological Disorders and Stroke (Grant Nos. 5U01NS040069-05 and 2R01NS040069-09) and the Office of the Director of the National Institutes of Health (1UG3OD023348-01). We also gratefully acknowledge the contributions of their subjects, and their subjects’ families, as well as those of their colleagues listed below. This study was supported by from the Office of the Director, National Institutes of Health (1UG3OD023348-01), the National Institute of Neurological Disorders and Stroke (5U01NS040069-05 and 2R01NS040069-09), and the National Institute of Child Health and Human Development (5P30HD018655-28). Dr. Frazier has the following disclosures: serving on the data safety monitoring board for Forest Pharmaceuticals and receiving research support from Alcobra, Janssen Pharmaceuticals, Neuren, and SyneuRX International.

ELGAN Study Investigators

Bhahvesh Shah, Rachana Singh, Linda Van Marter, Camilla Martin, Janice Ware, Cynthia Cole, Ellen Perrin, Frank Bednarek, Jean Frazier, Richard Ehrenkranz, Jennifer Benjamin, T. Michael O’Shea, Carl Bose, Diane Warner, Steve Engelke, Mariel Poortenga, Steve Pastyrnak, Padu Karna, Nigel Paneth, Madeleine Lenski, Michael Schreiber, Scott Hunter, Michael Msall, Danny Batton, Judith Klarr, Karen Christianson, Deborah Klein, Maureen Pimental, Collen Hallisey, Taryn Coster, Ellen Nylen, Emily Neger, Kathryn Mattern, Lauren Venuti, Beth Powers, Ann Foley, Joanne Williams, Elaine Romano, Debbie Hiatt, Nancy Peters, Patricia Brown, Emily Ansusinha, Gennie Bose, Janice Wereszczak, Janice Bernhardt, Joan Adams, Donna Wilson, Nancy Darden-Saad, Dinah Sutton, Julie Rathbun, Karen Miras, Deborah Weiland, Grace Yoon, Rugile Ramoskaite, Suzanne Wiggins, Krissy Washington, Ryan Martin, Barbara Prendergast, Beth Kring, Anne Smith, Susan McQuiston, Samantha Butler, Rachel Wilson, Kirsten McGhee, Patricia Lee, Aimee Asgarian, Anjali Sadhwani, Brandi Henson, Cecelia Keller, Jenifer Walkowiak, Susan Barron, Alice Miller, Brian Dessureau, Molly Wood, Jill Damon-Minow, Elaine Romano, Linda Mayes, Kathy Tsatsanis, Katarzyna Chawarska, Sophy Kim, Susan Dieterich, Karen Bearrs, Ellen Waldrep, Jackie Friedman, Gail Hounshell, Debbie Allred, Rebecca Helms, Lynn Whitley, Gary Stainback, Lisa Bostic, Amanda Jacobson, Joni McKeeman, Echo Meyer, Steve Pastyrnak, Joan Price, Megan Lloyd, Susan Plesha-Troyke, Megan Scott, KatherineM. Solomon, Kara Brooklier, Kelly Vogt.

Author information

Author notes

  1. Authors Joan Adams and Debbie Hiatt are deceased.

Authors and Affiliations

  1. Department of Pediatrics, University of North Carolina, Chapel Hill, NC, USA

    Thomas M. O’Shea

  2. Department of Psychology and Neuroanatomy, Boston University, Boston, USA

    Robert M. Joseph

  3. Department of Neurology, Harvard Medical School, Boston, MA, USA

    Elizabeth N. Allred & Alan Leviton

  4. Department of Neurology, Neuroepidemiology Unit, Boston Children’s Hospital, Boston, MA, USA

    Elizabeth N. Allred & Alan Leviton

  5. Department of Pediatrics, Rainbow Babies & Children’s Hospital, University Hospitals Cleveland Medical Center, Cleveland, OH, 44106, USA

    H. Gerry Taylor

  6. Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA

    Tim Heeren

  7. Division of Pediatric Neurology, Department of Pediatrics, Boston Medical Center, Boston, MA, USA

    Laurie M. Douglass & Karl C. K. Kuban

  8. Department of Psychiatry and Pediatrics, UMASS Medical School/ University of Massachusetts Memorial Children’s Medical Center, Worcester, MA, USA

    Jean A. Frazier

  9. Department of Radiology, Boston Medical Center, Boston University, Boston, USA

    Hernan Jara

  10. Baystate Medical Center, Springfield, MA, USA

    Bhahvesh Shah, Rachana Singh, Karen Christianson, Deborah Klein, Anne Smith & Susan McQuiston

  11. Boston Children’s Hospital, Boston, MA, USA

    Linda Van Marter, Camilla Martin, Janice Ware, Maureen Pimental, Collen Hallisey, Taryn Coster, Samantha Butler, Rachel Wilson, Kirsten McGhee, Patricia Lee, Aimee Asgarian, Anjali Sadhwani & Brandi Henson

  12. Tufts Medical Center, Boston, MA, USA

    Cynthia Cole, Ellen Perrin, Ellen Nylen, Emily Neger, Kathryn Mattern, Cecelia Keller, Jenifer Walkowiak & Susan Barron

  13. University of Massachusetts Medical School, Worcester, MA, USA

    Frank Bednarek, Jean Frazier, Lauren Venuti, Beth Powers, Ann Foley, Alice Miller, Brian Dessureau, Molly Wood & Jill Damon-Minow

  14. Yale University School of Medicine, New Haven, CT, USA

    Richard Ehrenkranz, Jennifer Benjamin, Joanne Williams, Elaine Romano, Elaine Romano, Linda Mayes, Kathy Tsatsanis, Katarzyna Chawarska, Sophy Kim, Susan Dieterich & Karen Bearrs

  15. Wake Forest University, Winston-Salem, NC, USA

    T. Michael O’Shea, Debbie Hiatt, Nancy Peters, Patricia Brown & Emily Ansusinha

  16. University of North Carolina, Chapel Hill, NC, USA

    Carl Bose, Diane Warner, Gennie Bose, Janice Wereszczak & Janice Bernhardt

  17. East Carolina University, Greenville, NC, USA

    Steve Engelke, Joan Adams, Donna Wilson & Nancy Darden-Saad

  18. Helen DeVos Children’s Hospital, Grand Rapids, MI, USA

    Mariel Poortenga, Steve Pastyrnak, Dinah Sutton, Julie Rathbun & Steve Pastyrnak

  19. Sparrow Hospital, East Lansing, MI, USA

    Padu Karna, Nigel Paneth, Madeleine Lenski, Karen Miras & Deborah Weiland

  20. University of Chicago Medical Center, Chicago, IL, USA

    Michael Schreiber, Scott Hunter, Michael Msall, Grace Yoon, Rugile Ramoskaite, Suzanne Wiggins, Krissy Washington, Ryan Martin, Barbara Prendergast, Susan Plesha-Troyke & Megan Scott

  21. William Beaumont Hospital, Royal Oak, MI, USA

    Danny Batton, Judith Klarr, Beth Kring, Katherine M. Solomon, Kara Brooklier & Kelly Vogt

  22. Wake Forest University Baptist Medical Center, Winston-Salem, NC, USA

    Ellen Waldrep, Jackie Friedman, Gail Hounshell & Debbie Allred

  23. University Health Systems of Eastern Carolina, Greenville, NC, USA

    Rebecca Helms, Lynn Whitley & Gary Stainback

  24. University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Lisa Bostic, Amanda Jacobson, Joni McKeeman & Echo Meyer

  25. Sparrow Hospital, Lansing, MI, USA

    Joan Price & Megan Lloyd

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  1. Thomas M. O’Shea
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  2. Robert M. Joseph
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  3. Elizabeth N. Allred
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  4. H. Gerry Taylor
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  5. Alan Leviton
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  6. Tim Heeren
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  7. Laurie M. Douglass
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  8. Jean A. Frazier
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  9. Hernan Jara
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  10. Karl C. K. Kuban
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Consortia

for the ELGAN Study Investigators

  • Bhahvesh Shah
  • , Rachana Singh
  • , Linda Van Marter
  • , Camilla Martin
  • , Janice Ware
  • , Cynthia Cole
  • , Ellen Perrin
  • , Frank Bednarek
  • , Jean Frazier
  • , Richard Ehrenkranz
  • , Jennifer Benjamin
  • , T. Michael O’Shea
  • , Carl Bose
  • , Diane Warner
  • , Steve Engelke
  • , Mariel Poortenga
  • , Steve Pastyrnak
  • , Padu Karna
  • , Nigel Paneth
  • , Madeleine Lenski
  • , Michael Schreiber
  • , Scott Hunter
  • , Michael Msall
  • , Danny Batton
  • , Judith Klarr
  • , Karen Christianson
  • , Deborah Klein
  • , Maureen Pimental
  • , Collen Hallisey
  • , Taryn Coster
  • , Ellen Nylen
  • , Emily Neger
  • , Kathryn Mattern
  • , Lauren Venuti
  • , Beth Powers
  • , Ann Foley
  • , Joanne Williams
  • , Elaine Romano
  • , Debbie Hiatt
  • , Nancy Peters
  • , Patricia Brown
  • , Emily Ansusinha
  • , Gennie Bose
  • , Janice Wereszczak
  • , Janice Bernhardt
  • , Joan Adams
  • , Donna Wilson
  • , Nancy Darden-Saad
  • , Dinah Sutton
  • , Julie Rathbun
  • , Karen Miras
  • , Deborah Weiland
  • , Grace Yoon
  • , Rugile Ramoskaite
  • , Suzanne Wiggins
  • , Krissy Washington
  • , Ryan Martin
  • , Barbara Prendergast
  • , Beth Kring
  • , Anne Smith
  • , Susan McQuiston
  • , Samantha Butler
  • , Rachel Wilson
  • , Kirsten McGhee
  • , Patricia Lee
  • , Aimee Asgarian
  • , Anjali Sadhwani
  • , Brandi Henson
  • , Cecelia Keller
  • , Jenifer Walkowiak
  • , Susan Barron
  • , Alice Miller
  • , Brian Dessureau
  • , Molly Wood
  • , Jill Damon-Minow
  • , Elaine Romano
  • , Linda Mayes
  • , Kathy Tsatsanis
  • , Katarzyna Chawarska
  • , Sophy Kim
  • , Susan Dieterich
  • , Karen Bearrs
  • , Ellen Waldrep
  • , Jackie Friedman
  • , Gail Hounshell
  • , Debbie Allred
  • , Rebecca Helms
  • , Lynn Whitley
  • , Gary Stainback
  • , Lisa Bostic
  • , Amanda Jacobson
  • , Joni McKeeman
  • , Echo Meyer
  • , Steve Pastyrnak
  • , Joan Price
  • , Megan Lloyd
  • , Susan Plesha-Troyke
  • , Megan Scott
  • , Katherine M. Solomon
  • , Kara Brooklier
  •  & Kelly Vogt

Corresponding author

Correspondence to Thomas M. O’Shea.

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O’Shea, T.M., Joseph, R.M., Allred, E.N. et al. Accuracy of the Bayley-II mental development index at 2 years as a predictor of cognitive impairment at school age among children born extremely preterm. J Perinatol 38, 908–916 (2018). https://doi.org/10.1038/s41372-017-0020-8

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