Clinical—Liver, Pancreas, and Biliary TractInhibitory Control Test for the Diagnosis of Minimal Hepatic Encephalopathy
Section snippets
Patients and Methods
Outpatients with cirrhosis were recruited between September 2004 and December 2007 through clinical referral. Patients between ages 18 and 65 years, without current psychoactive drug use, not on OHE treatments, without history of OHE, and without alcohol use within 3 months were included.
Cross-Sectional Study of the SPT and ICT for Diagnosing MHE
Within the cirrhotic patients, there were 8 patients between 18 and 35 years, 67 between 36 and 55 years, and 48 patients between 56 and 65 years of age. Of the 116 controls, 23 were between 18 and 35 years, 66 between 36 and 55 years, and 27 between 56 and 65 years of age.
Discussion
The current study demonstrates that the ICT is simple to administer and has a high sensitivity, area under the curve for diagnosis, and test-retest reliability for the diagnosis of MHE compared with SPT. ICT has external validity for MHE because it predicts OHE development, improves after successful MHE therapy, and worsens after TIPS placement. This study also demonstrates that ICT can be administered in clinics by MAs after a single training session, which makes ICT a less expensive method
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Supported in part by GCRC grant number M01-RR00058 and by the New Investigator Research Affairs Committee grant at the Medical College of Wisconsin (to J.S.B.).
The authors disclose no conflicts.