Minim Invasive Neurosurg 2009; 52(4): 170-175
DOI: 10.1055/s-0029-1237366
Original Article

© Georg Thieme Verlag KG Stuttgart · New York

Histological Demonstration of Healing in Experimental Aneurysms

M. Killer1 , H. Plenk2 , B. Minnich3 , R. Al-Schameri4 , A. Lametschwantner3 , B. Richling4
  • 1Department of Neurology/Neuroscience Institute, Christian Doppler Clinic, Paracelsus Medical University, Salzburg, Austria
  • 2Bone & Biomaterials Research, Institute for Histology and Embryology, Medical University of Vienna, Vienna, Austria
  • 3Institute for Organismic Biology, University of Salzburg, Salzburg, Austria
  • 4Department of Neurosurgery, Christian Doppler Clinic, Paracelsus Medical University, Salzburg, Austria
Further Information

Publication History

Publication Date:
16 October 2009 (online)

Abstract

Introduction: Recanalisation of aneurysms after interventional therapy is still an unsolved problem. The aim of this study is to demonstrate the angiographic and histological evidence of healing after endovascular embolisation of experimental aneurysms.

Methods: We evaluated the healing reaction in experimental aneurysms treated with HydroCoils and platinum coils. After microsurgical construction of aneurysms in 24 rabbits, embolisation was performed. Four animals were sacrificed immediately after embolisation and 5 after 1 month, 3 months and 6 months, respectively, the remaining served as control group. Serial plastic-embedded ground sections of the parent arteries-aneurysm complexes were evaluated by light microscopy.

Results: Thrombus organisation in the aneurysms resulted in fibrovascular tissue formation between bare platinum and HydroCoils from the walls of the aneurysms towards the centre of the sac over time. In the clefts between HydroCoils only thin strands of granulation tissue were observed. From one month on, there was a neointimal layer covering the coil mass at the aneurysm orifice.

Conclusion: Progressive occlusion by the expanding hydrogel polymers on the coils seemed to result in a durable healing reaction in the aneurismal sac in a short-term follow-up period.

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Correspondence

M. KillerMD 

Department of Neurology/Neuroscience Institute

Christian Doppler Clinic

Paracelsus Medical University

Ignaz-Harrer Straße 79

5020 Salzburg

Austria

Phone: +43/662/4483 560 58

Fax: +43/662/4483 30 04

Email: m.killer@salk.at

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