Neuropediatrics 2002; 33(2): 97-99
DOI: 10.1055/s-2002-32370
Short Communication

Georg Thieme Verlag Stuttgart · New York

Cerebral Venous Thrombosis, Intraventricular Haemorrhage and White Matter Lesions in a Preterm Newborn with Factor V (Leiden) Mutation

L. A. Ramenghi1 , B. J. Gill1 , S. F. Tanner3 , D. Martinez2 , R. Arthur2 , M. I. Levene1
  • 1 Paediatric Department, University of Leeds, General Infirmary at Leeds, Leeds, UK
  • 2 Radiology Department, University of Leeds, General Infirmary at Leeds, Leeds, UK
  • 3 Magnetic Resonance Department, University of Leeds, General Infirmary at Leeds, Leeds, UK
Further Information

Publication History

Publication Date:
20 June 2002 (online)

Abstract

We report a preterm newborn who presented extensive cerebral vein thrombosis on MRI but no abnormal neurological signs. The baby underwent MRI as germinal-matrix intraventricular haemorrhage was revealed by a routine ultrasound brain scan performed on day 16; earlier ultrasound scans (day 2, 7, 12) were all normal. Cerebral vein thrombosis was diagnosed at the first MRI scan together with abnormal restriction in diffusion weighted imaging in the frontal white matter parenchyma. Bilateral microcavitations with a linear pattern of distribution reflecting the distribution of medullary veins developed a week later in the same white matter areas where abnormal diffusion weighted imaging was formerly noted. The baby was later found to be heterozygous for factor V Leiden.

References

  • 1 Barkovich A J. Brain and spine injuries in infancy and childhood. Barkovich AJ Pediatric Neuroimaging. Philadelphia; Lippincott Williams & Wilkin 2000: 157-251
  • 2 Baumeister F A, Auberger K, Schneider K. Thrombosis of the deep cerebral veins with excessive bilateral infarction in a premature infant with the thrombogenic 4 G/4 G genotype of the plasminogen activator inhibitor-1.  Eur J Pediatr. 2000;  159 239-242
  • 3 Debus O, Kock H G, Kurlemann Strater R, Vielhaber H, Weber P, Nowak-Gottl U. Factor V Leiden and genetic defects of thrombophilia in childood poroencephaly.  Arch Dis Child. 1998;  78 F121-F124
  • 4 Deveber G, Andrew M, Adams C, Bjornson B, Booth F, Buckley D J, Camfield C S, David M, Humphreys P, Langevin P, MacDonald E A, Gillet J. Cerebral sinovenous thrombosis in children.  N Engl J Med. 2001;  345 417-422
  • 5 Ducreux D, Oppenheim C, Vandamme X, Dormont D, Samson D, Rancurei G, Cosnard G, Marsault C. Diffusion-weighted imaging pattern of brain damage associated with cerebral venous thrombosis.  AJNR Am J Neuroradiol. 2001;  22 261-268
  • 6 Ghazi-Birry H S, Brown W R, Moody D M, Challa V R, Block S M, Reboussin D M. Human germinal matrix: Venous origin of hemorrhage and vascular characteristics.  AJNR Am J Neuroradiol. 1997;  18 219-229
  • 7 Harum K H, Casella J F. Factor V Leiden: a risk factor for cerebral palsy.  Dev Med Child Neurol. 1999;  41 781-785
  • 8 Levene M I, de Vries L S. Neonatal intracranial haemorrhages. Levene MI Fetal and Neonatal Neurology and Neurosurgery. Edinburgh; Churchill Livingstone 1995: 335-366
  • 9 Pohl M, Zimmerhackl L B, Heinen F, Sutor A H, Schneppenheim R, Brandis M. Bilateral renal vein thrombosis and venous sinus thrombosis in a neonate with factor V mutation (FV Leiden).  J Pediatr. 1998;  132 159-161
  • 10 Rivkin M J, Anderson M L, Kaye E M. Neonatal idiopathic cerebral venous thrombosis: an unrecognized cause of transient seizures or lethargy.  Ann Neurol. 1992;  32 51-56
  • 11 Salooja N, Martin P, Khair K, Liesner R, Hann I. Severe factor V deficiency and neonatal intracranial haemorrhage: a case report.  Haemophilia. 2000;  6 44-46
  • 12 Thoransensen O, Ryan S, Hunters J, Younkin D P. Factor V Leiden mutation: an unrecognized cause of hemiplegic cerebral palsy, neonatal stroke, and placental thrombosis.  Ann Neurol. 1997;  42 372-375
  • 13 Volpe J J. Hypoxic-ischemic encephalopathy: Neuropathology and pathogenesis. Volpe JJ Neurology of the Newborn. Philadelphia; Saunders 1995: 279-313

Dr. L. A. Ramenghi

16 Via Palazzolo

24122 Bergamo

Italy

Email: lucrameng@hotmail.com

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