Mitochondria in the life and death of neurons

S L Budd; D G Nicholls

doi:10.1042/bse0330043

Mitochondria in the life and death of neurons

Essays Biochem. 1998:33:43-52. doi: 10.1042/bse0330043.

Authors

S L Budd¹, D G Nicholls

Affiliation

¹ CNS Research Institute, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

PMID: 10488440
DOI: 10.1042/bse0330043

Abstract

A prolonged decrease in ATP levels underlies a number of neurodegenerative disorders. Defects in oxidative phosphorylation are associated with a number of neurodegenerative disorders. Mitochondria also play an important role in mediating the initiation of apoptosis.

Publication types

Review

MeSH terms

Alzheimer Disease / etiology
Animals
Apoptosis / physiology
Energy Metabolism
Humans
Mitochondria / metabolism*
Mitochondrial Myopathies / etiology
Models, Neurological
Neurodegenerative Diseases / etiology
Neurons / cytology*
Neurons / metabolism*
Parkinson Disease / etiology
Receptors, N-Methyl-D-Aspartate / metabolism

Substances

Receptors, N-Methyl-D-Aspartate