A broadband phased-array system for direct phosphorus and sodium metabolic MRI on a clinical scanner

Magn Reson Med. 2000 Feb;43(2):269-77. doi: 10.1002/(sici)1522-2594(200002)43:2<269::aid-mrm14>3.0.co;2-j.

Abstract

Despite their proven gains in signal-to-noise ratio and field-of-view for routine clinical MRI, phased-array detection systems are currently unavailable for nuclei other than protons (1H). A broadband phased-array system was designed and built to convert the 1H transmitter signal to the non-1H frequency for excitation and to convert non-1H phased-array MRI signals to the 1H frequency for presentation to the narrowband 1H receivers of a clinical whole-body 1.5 T MRI system. With this system, the scanner operates at the 1H frequency, whereas phased-array MRI occurs at the frequency of the other nucleus. Pulse sequences were developed for direct phased-array sodium (23Na) and phosphorus (31P) MRI of high-energy phosphates using chemical selective imaging, thereby avoiding the complex processing and reconstruction required for phased-array magnetic resonance spectroscopy data. Flexible 4-channel 31P and 23Na phased-arrays were built and the entire system tested in phantom and human studies. The array produced a signal-to-noise ratio improvement of 20% relative to the best-positioned single coil, but gains of 300-400% were realized in many voxels located outside the effective field-of-view of the single coil. Cardiac phosphorus and sodium MRI were obtained in 6-13 min with 16 and 0.5 mL resolution, respectively. Lower resolution human cardiac 23Na MRI were obtained in as little as 4 sec. The system provides a practical approach to realizing the advantages of phased-arrays for nuclei other than 1H, and imaging metabolites directly.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amplifiers, Electronic
  • Artifacts
  • Equipment Design
  • Female
  • Heart / anatomy & histology*
  • Humans
  • Magnetic Resonance Imaging / instrumentation*
  • Magnetic Resonance Imaging / methods
  • Magnetic Resonance Imaging / statistics & numerical data
  • Magnetic Resonance Spectroscopy / instrumentation*
  • Magnetic Resonance Spectroscopy / methods
  • Magnetic Resonance Spectroscopy / statistics & numerical data
  • Male
  • Myocardium / metabolism*
  • Phosphorus / metabolism*
  • Phosphorus Radioisotopes
  • Sodium / metabolism*
  • Sodium Isotopes
  • Software

Substances

  • Phosphorus Radioisotopes
  • Sodium Isotopes
  • Phosphorus
  • Sodium