Abstract
Recent studies, particularly of genetically altered mice, have greatly improved our understanding of the molecular basis underlying the development of the vascular system. Endothelial signalling systems, such as the vascular endothelial growth factor (VEGF)/VEGF receptor system and the angiopoietin/Tie2 system, were identified as central regulators of embryonic angiogenesis. The complex interactions between these and other endothelial signalling systems are beginning to emerge. Placenta (2000), 21, Supplement A, Trophoblast Research, 14, S11-S15.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Angiopoietin-1
-
Animals
-
Antigens, CD
-
Cadherins / genetics
-
Cadherins / physiology
-
Embryonic and Fetal Development* / genetics
-
Embryonic and Fetal Development* / physiology
-
Endothelial Growth Factors / genetics
-
Endothelial Growth Factors / physiology
-
Female
-
Humans
-
Lymphokines / genetics
-
Lymphokines / physiology
-
Membrane Glycoproteins / genetics
-
Membrane Glycoproteins / physiology
-
Mice
-
Mice, Knockout
-
Neoplasm Proteins / genetics
-
Neoplasm Proteins / physiology
-
Neovascularization, Physiologic* / genetics
-
Pregnancy
-
Proto-Oncogene Proteins*
-
Receptor Protein-Tyrosine Kinases / genetics
-
Receptor Protein-Tyrosine Kinases / physiology
-
Receptor, TIE-2
-
Receptors, Growth Factor / genetics
-
Receptors, Growth Factor / physiology
-
Receptors, Vascular Endothelial Growth Factor
-
Signal Transduction
-
Vascular Endothelial Growth Factor A
-
Vascular Endothelial Growth Factors
Substances
-
Angiopoietin-1
-
Angpt1 protein, mouse
-
Antigens, CD
-
Cadherins
-
Endothelial Growth Factors
-
Lymphokines
-
MEN1 protein, human
-
Membrane Glycoproteins
-
Neoplasm Proteins
-
Proto-Oncogene Proteins
-
Receptors, Growth Factor
-
Vascular Endothelial Growth Factor A
-
Vascular Endothelial Growth Factors
-
cadherin 5
-
Receptor Protein-Tyrosine Kinases
-
Receptor, TIE-2
-
Receptors, Vascular Endothelial Growth Factor