Two functional magnetic resonance imaging f(MRI) tasks that may replace the gold standard, Wada testing, for language lateralization while giving additional localization information

Brain Cogn. 2000 Jun-Aug;43(1-3):57-9.

Abstract

Two tasks were used to lateralize and localize language functions noninvasively, using functional magnetic resonance (fMRI BOLD sequences). fMRI images produced during comprehension of the gist of a tale derived from an ordered series of inferential questions were used to lateralize and locate the center of and margins within language dominant hemisphere near posterior temporal-parietal-occipital (TPO) cortical area(s), e.g., Wernicke's. A silent noun-generating task was used to lateralize and localize naming functions within and along superior temporal gyrus (STG) and/or the basal temporal language area (BTLA) in fusiform gyrus. Used within a series of tasks, their purpose was to investigate the reliability and validity of replacing the invasive gold standard for language lateralization, Wada test, with a noninvasive test, BOLD fMRI.

MeSH terms

  • Adolescent
  • Adult
  • Amobarbital*
  • Brain / anatomy & histology
  • Brain / physiology*
  • Female
  • Functional Laterality / physiology*
  • GABA Modulators*
  • Humans
  • Language*
  • Magnetic Resonance Imaging / methods*
  • Male
  • Occipital Lobe / anatomy & histology
  • Occipital Lobe / physiology
  • Parietal Lobe / anatomy & histology
  • Parietal Lobe / physiology
  • Reproducibility of Results
  • Temporal Lobe / anatomy & histology
  • Temporal Lobe / physiology

Substances

  • GABA Modulators
  • Amobarbital