Abstract
Rodent studies have shown that lithium exerts neurotrophic or neuroprotective effects. We used three-dimensional magnetic resonance imaging and brain segmentation to study pharmacologically-induced increases in grey matter volume with chronic lithium use in patients with bipolar mood disorder. Grey-matter volume increased after 4 weeks of treatment. The increases in grey matter probably occurred because of neurotrophic effects.
Publication types
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Clinical Trial
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Letter
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Adult
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Aspartic Acid / analogs & derivatives*
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Aspartic Acid / drug effects
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Aspartic Acid / metabolism
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Bipolar Disorder / drug therapy*
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Brain / drug effects
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Brain / metabolism
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Female
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Humans
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Lithium / therapeutic use*
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Neuroprotective Agents / therapeutic use
Substances
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Neuroprotective Agents
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Aspartic Acid
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N-acetylaspartate
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Lithium