Expression of the Sox10 gene during mouse inner ear development

K Watanabe; K Takeda; Y Katori; K Ikeda; T Oshima; K Yasumoto; H Saito; T Takasaka; S Shibahara

doi:10.1016/s0169-328x(00)00236-9

Expression of the Sox10 gene during mouse inner ear development

Brain Res Mol Brain Res. 2000 Dec 8;84(1-2):141-5. doi: 10.1016/s0169-328x(00)00236-9.

Authors

K Watanabe¹, K Takeda, Y Katori, K Ikeda, T Oshima, K Yasumoto, H Saito, T Takasaka, S Shibahara

Affiliation

¹ Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.

PMID: 11113541
DOI: 10.1016/s0169-328x(00)00236-9

Abstract

Mutations in the SOX10 gene, encoding a cell-lineage specific transcription factor, are associated with congenital deafness. We analyzed the expression of Sox10 mRNA in developing mouse inner ear by in situ hybridization. Sox10 mRNA is expressed in the entire epithelia of the otic vesicle at embryonic day 11.5 (E11.5) and in the developing cochlea and vestibule at E13.5. In postnatal day 8 and adult cochleas, Sox10 expression is restricted to the supporting cells of the organ of Corti. These expression profiles suggest that Sox10 is important for development of the cochlea.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cochlea / embryology
Cochlea / growth & development
Cochlea / metabolism
DNA-Binding Proteins / genetics*
Ear, Inner / embryology*
Ear, Inner / growth & development*
Ear, Inner / metabolism
Gene Expression Regulation, Developmental*
High Mobility Group Proteins / genetics*
In Situ Hybridization
Mice
Mice, Inbred BALB C
RNA Probes
RNA, Antisense / genetics
RNA, Messenger / genetics
RNA, Messenger / metabolism
SOXE Transcription Factors
Transcription Factors

Substances

DNA-Binding Proteins
High Mobility Group Proteins
RNA Probes
RNA, Antisense
RNA, Messenger
SOXE Transcription Factors
Sox10 protein, mouse
Transcription Factors