The aim of this study was to determine flow characteristics and pressure gradients of different balloon- and self-expandable stents in an in vitro flow-model. Seven vascular stents (Bridge, Cragg, Memotherm, Palmaz PS 784, Sinus, Symphony, Wallstent), equal in length (60 mm) and diameter (10 mm), were deployed in a closed flow model. The inner diameter of the tube measured 9 mm. Flow at 1.5 and 6 l/min was applied. Flow patterns were visualized by anionic particles illuminated with two helium-neon lasers. Late laminary flow characteristics and pre-/post-stent pressure gradients were determined in either expanded stent, 25 and 50% tube stenosis. Stent implantation induced a decrease of laminary flow when compared with an unstented tube with and without concentric 25% stenosis (p < 0.01) at all flow rates and an increase of pressure gradients when compared with an unstented tube for a flow rate of 6 l/min and all stenoses (p < 0.01). At 1.5 l/min most stents revealed no significant change of pressure gradient, the highest gradient measured 4.0 mmHg. Sinus permitted maximum (expanded: 82.1% and 76.9% at 25% stenosis at 1.5 l/min; p < 0.01) and Palmaz minimum of laminary flow at all flow rates and stenoses (70.2 and 52.4% at 25% stenosis at 1.5 l/min; p < 0.01). At 6 l/min, when completely expanded, Sinus is equal to Bridge and Memotherm; in 25% stenosis Sinus is equal to Bridge, Memotherm, and additionally to Cragg and Wall. None of the endoprostheses revealed laminary flow at 50% stenosis. Inadequate stent deployment bears the risk of creating less laminary flow and pressure gradients. Since flow disturbances and pressure gradients may influence neointimal hyperplasia, stent design and completeness of stent expansion are important factors regarding the appearance of thrombus formation and postinterventional restenosis.