Clinical application of procedural platelet monitoring during percutaneous coronary intervention among patients at increased bleeding risk

J Thromb Thrombolysis. 2001 Apr;11(2):151-4. doi: 10.1023/a:1011228817265.

Abstract

The goal of platelet function testing in the catheterization laboratory is to provide information about the platelet contributions to the risk of thrombotic or hemorrhagic events and optimization of anti-platelet therapy for percutaneous interventions. We present several illustrative cases in which platelet monitoring with the Rapid Platelet Function Assay (RPFA, Accumetrics) was used to guide dosing of a glycoprotein (GP) IIb/IIIa inhibitor for coronary and peripheral intervention among patients at increased bleeding risk.

Publication types

  • Case Reports

MeSH terms

  • Abciximab
  • Adult
  • Aged
  • Aged, 80 and over
  • Angina, Unstable / surgery
  • Angioplasty, Balloon, Coronary*
  • Antibodies, Monoclonal / administration & dosage
  • Antibodies, Monoclonal / adverse effects
  • Antibodies, Monoclonal / pharmacology
  • Antibodies, Monoclonal / therapeutic use*
  • Anticoagulants / administration & dosage
  • Anticoagulants / adverse effects
  • Anticoagulants / therapeutic use
  • Aspirin / administration & dosage
  • Aspirin / adverse effects
  • Aspirin / therapeutic use
  • Carotid Stenosis / surgery
  • Clopidogrel
  • Comorbidity
  • Coronary Artery Bypass
  • Drug Therapy, Combination
  • Female
  • Fibrinogen
  • Graft Occlusion, Vascular / surgery
  • Hemorrhage / chemically induced
  • Hemorrhage / prevention & control*
  • Humans
  • Immunoglobulin Fab Fragments / administration & dosage
  • Immunoglobulin Fab Fragments / adverse effects
  • Immunoglobulin Fab Fragments / pharmacology
  • Immunoglobulin Fab Fragments / therapeutic use*
  • Male
  • Microspheres
  • Peptide Fragments / pharmacology
  • Platelet Aggregation Inhibitors / administration & dosage
  • Platelet Aggregation Inhibitors / adverse effects
  • Platelet Aggregation Inhibitors / pharmacology
  • Platelet Aggregation Inhibitors / therapeutic use*
  • Platelet Count
  • Platelet Function Tests* / instrumentation
  • Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors*
  • Recurrence
  • Risk
  • Stents
  • Ticlopidine / administration & dosage
  • Ticlopidine / adverse effects
  • Ticlopidine / analogs & derivatives
  • Ticlopidine / therapeutic use

Substances

  • Antibodies, Monoclonal
  • Anticoagulants
  • Immunoglobulin Fab Fragments
  • Peptide Fragments
  • Platelet Aggregation Inhibitors
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • thrombin receptor peptide (42-47)
  • Fibrinogen
  • Clopidogrel
  • Ticlopidine
  • Aspirin
  • Abciximab