Abstract
Although the exact causative phenomenon responsible for the onset and progression of neurodegenerative disorders is at present unresolved, there are some clues as to the mechanisms underlying these chronic diseases. This review addresses mechanisms by which endogenous or environmental factors, through interaction with redox active metals, may initiate a common cascade of events terminating in neurodegeneration.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Aging / metabolism
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Aging / pathology
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Animals
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Encephalitis / chemically induced*
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Encephalitis / pathology
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Encephalitis / physiopathology
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Humans
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Metals / toxicity*
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Nerve Tissue Proteins / biosynthesis
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Nerve Tissue Proteins / metabolism
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Neurodegenerative Diseases / chemically induced*
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Neurodegenerative Diseases / pathology
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Neurodegenerative Diseases / physiopathology
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Reactive Oxygen Species / metabolism*
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Trace Elements / toxicity*
Substances
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Metals
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Nerve Tissue Proteins
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Reactive Oxygen Species
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Trace Elements