Slice-selective J-coupled coherence transfer using symmetric linear phase pulses: applications to localized GABA spectroscopy

J Magn Reson. 2003 Jul;163(1):73-80. doi: 10.1016/s1090-7807(03)00112-5.

Abstract

Symmetric, linear phase, slice-selective RF pulses were analyzed theoretically for performing slice-selective coherence transfer. It was shown using numerical simulations of product operators that, when a prefocusing gradient of the same area as that of the refocusing gradient is added, these pulses become slice-selective universal rotator pulses, therefore, capable of performing slice-selective coherence transfer. As an example, a slice-selective universal rotator pulse based on a seven-lobe hamming-filtered sinc pulse was applied to in vivo single-shot simultaneous spectral editing and spatial localization of neurotransmitter GABA in the human brain.

Publication types

  • Evaluation Study

MeSH terms

  • Algorithms*
  • Brain Chemistry*
  • Computer Simulation
  • Energy Transfer
  • Linear Models
  • Magnetic Resonance Spectroscopy / methods*
  • Magnetics
  • Models, Chemical
  • Models, Molecular*
  • Radio Waves
  • Signal Processing, Computer-Assisted*
  • gamma-Aminobutyric Acid / analysis*
  • gamma-Aminobutyric Acid / chemistry*

Substances

  • gamma-Aminobutyric Acid