The purpose of this study was to quantitatively evaluate in a phantom model the practical impact of alteration of key imaging parameters on image quality and artifacts for the most commonly used fast T(2)-weighted MR sequences. These include fast spin-echo (FSE), single shot fast spin-echo (SSFSE), and spin-echo echo-planar imaging (EPI) pulse sequences. We developed a composite phantom with different T1 and T2 values, which was evaluated while stationary as well as during periodic motion. Experiments involved controlled variations in key parameters including effective TE, TR, echo spacing (ESP), receive bandwidth (BW), echo train length (ETL), and shot number (SN). Quantitative analysis consisted of signal-to-noise ratio (SNR), image nonuniformity, full-width-at-half-maximum (i.e., blurring or geometric distortion) and ghosting ratio. Among the fast T(2)-weighted sequences, EPI was most sensitive to alterations in imaging parameters. Among imaging parameters that we tested, effective TE, ETL, and shot number most prominently affected image quality and artifacts. Short T(2) objects were more sensitive to alterations in imaging parameters in terms of image quality and artifacts. Optimal clinical application of these fast T(2)-weighted imaging pulse sequences requires careful attention to selection of imaging parameters.