Abstract
Fisher syndrome (FS), a variant of Guillain-Barré syndrome (GBS), is a rare disorder, and there are few reported studies of a large number of patients with FS. Cerebrospinal fluid (CSF) albuminocytological dissociation was found in 59% of 123 FS patients during the first 3 weeks of illness, while serum anti-GQ1b IgG antibody was positive in 85%. Whereas the incidence of CSF albuminocytological dissociation increased from the first to second weeks in FS, anti-GQ1b IgG antibody peaked in the first week, but there was no CSF albuminocytological dissociation. Statistically, anti-GQ1b antibody testing was superior to a CSF examination in supporting a diagnosis of FS during the first 3 weeks of illness, especially in the first week.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adolescent
-
Adult
-
Age Factors
-
Aged
-
Aged, 80 and over
-
Albumins / cerebrospinal fluid
-
Analysis of Variance
-
Antibodies, Anti-Idiotypic / blood
-
Antibodies, Anti-Idiotypic / cerebrospinal fluid
-
Antibodies, Anti-Idiotypic / immunology
-
Child
-
Child, Preschool
-
Female
-
Gangliosides / immunology*
-
Guillain-Barre Syndrome / blood
-
Guillain-Barre Syndrome / cerebrospinal fluid
-
Guillain-Barre Syndrome / diagnosis
-
Guillain-Barre Syndrome / immunology
-
Humans
-
Immunoglobulin G / blood*
-
Infant
-
Infant, Newborn
-
Male
-
Middle Aged
-
Miller Fisher Syndrome / blood
-
Miller Fisher Syndrome / cerebrospinal fluid
-
Miller Fisher Syndrome / diagnosis*
-
Miller Fisher Syndrome / immunology
-
Statistics, Nonparametric
-
Time Factors
Substances
-
Albumins
-
Antibodies, Anti-Idiotypic
-
Gangliosides
-
Immunoglobulin G
-
GQ1b ganglioside