Image-guided spine interventions are being performed by radiologists and other physicians with increased frequency. This article assesses the use of several techniques and devices that can mitigate radiation exposure during interventional procedures. Measurements were obtained on a humanoid phantom with use of various shielding methods. Significant radiation dose reductions as great as 98.7% can be achieved with use of a combination of stationary and mobile lead barriers and operator position. The application of basic radiation physics in combination with prudent radiographic technique can significantly reduce radiation exposure to the operator and other personnel during spine interventions.