Severe neuroborreliosis: The benefit of prolonged high-dose combination of antimicrobial agents with steroids--an illustrative case

Diagn Microbiol Infect Dis. 2005 Feb;51(2):127-30. doi: 10.1016/j.diagmicrobio.2004.04.022.

Abstract

Neuroborreliosis frequently occurs in endemic areas, whereas encephalomyelitis is uncommon. Treatment consists classically of 2 to 4 weeks of recommended antimicrobial agents with a generally good outcome. A severe case is reported combining an encephalomyelitis with an axonal polyneuropathy. Clinical improvement was observed only with the use of prolonged high dose of 2 antimicrobial agents combined with steroids.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Borrelia burgdorferi / drug effects*
  • Borrelia burgdorferi / isolation & purification
  • Ceftriaxone / therapeutic use
  • Contrast Media
  • Dose-Response Relationship, Drug
  • Doxycycline / therapeutic use
  • Drug Administration Schedule
  • Drug Therapy, Combination / therapeutic use*
  • Follow-Up Studies
  • Humans
  • Lyme Neuroborreliosis / diagnosis*
  • Lyme Neuroborreliosis / drug therapy*
  • Male
  • Methylprednisolone / therapeutic use*
  • Risk Assessment
  • Severity of Illness Index
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Contrast Media
  • Ceftriaxone
  • Doxycycline
  • Methylprednisolone