Methods for magnetically labeling stem and other cells for detection by in vivo magnetic resonance imaging

Cytotherapy. 2004;6(6):621-5. doi: 10.1080/14653240410005267-1.

Abstract

Superparamagnetic iron oxide (SPIO) nanoparticles are being used for intracellular magnetic labeling of stem cells and other cells in order to monitor cell trafficking by magnetic resonance imaging (MRI) as part of cellular-based repair, replacement and treatment strategies. This review focuses on the various methods for magnetic labeling of stem cells and other mammalian cells and on how to translate experimental results from bench to bedside.

Publication types

  • Review

MeSH terms

  • Animals
  • Clinical Trials as Topic
  • Contrast Media / chemistry
  • Contrast Media / metabolism
  • Dextrans
  • Ferrosoferric Oxide
  • Humans
  • Iron / chemistry
  • Iron / metabolism
  • Magnetic Resonance Imaging / methods*
  • Magnetics*
  • Magnetite Nanoparticles
  • Molecular Probes / chemistry
  • Molecular Probes / metabolism
  • Oxides / chemistry
  • Oxides / metabolism
  • Staining and Labeling*
  • Stem Cells / cytology
  • Stem Cells / physiology*

Substances

  • Contrast Media
  • Dextrans
  • Magnetite Nanoparticles
  • Molecular Probes
  • Oxides
  • Iron
  • ferumoxides
  • Ferrosoferric Oxide