Abstract
We correlated serial brain MRIs with neuropathological findings in a 16-year-old female whose autopsy was consistent with Wernicke's encephalopathy (WE). Diffusion-weighted imaging, diffusion coefficients mapping and neuropathology findings were suggested vasogenic edema in the periaqueductal and peri-the-fourth ventricular areas. This is the first documented case report to make this direct comparison. The characteristic WE changes in the mammillary body was also correlated with the findings of MRI with contrast enhancement. Bilateral cortical lesions revealed by MRI were atypical and rare in WE and were not evidenced by pathological changes.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Anti-Bacterial Agents / therapeutic use
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Autonomic Nervous System Diseases / etiology
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Autonomic Nervous System Diseases / physiopathology
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Brain / metabolism
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Brain / pathology*
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Brain / physiopathology
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Brain Edema / etiology
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Brain Edema / pathology
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Brain Edema / physiopathology
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Brain Stem / blood supply
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Brain Stem / pathology
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Brain Stem / physiopathology
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Cardiovascular Diseases / etiology
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Cardiovascular Diseases / physiopathology
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Diagnosis, Differential
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Diffusion Magnetic Resonance Imaging / methods*
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Early Diagnosis
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Encephalomyelitis, Acute Disseminated / diagnosis
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Encephalomyelitis, Acute Disseminated / therapy
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Fatal Outcome
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Female
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Humans
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Intracranial Hemorrhages / etiology
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Intracranial Hemorrhages / pathology
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Intracranial Hemorrhages / physiopathology
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Mammillary Bodies / blood supply
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Mammillary Bodies / pathology
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Mammillary Bodies / physiopathology
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Methylprednisolone / therapeutic use
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Treatment Failure
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Vomiting / complications
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Vomiting / physiopathology
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Wernicke Encephalopathy / etiology
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Wernicke Encephalopathy / pathology*
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Wernicke Encephalopathy / physiopathology
Substances
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Anti-Bacterial Agents
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Methylprednisolone