Management of Twin-Twin Transfusion Syndrome (TTTS) is one of the most challenging clinical problems concerning multiple gestations. The pathophysiology of TTTS and Quintero staging system are described. The importance of fetal echocardiograms in assessing prognosis and response to therapy is highlighted. Treatment modalities, particularly amnioreduction, microseptostomy, and fetoscopic laser photocoagulation, are discussed. Questions still remain as to how various treatment options affect short- and long-term cardiac and neurodevelopmental outcomes and which patients will benefit most from selective laser photocoagulation therapy.