Management of intracranial meningeal hemangiopericytomas: outcome and experience

Neurosurg Rev. 2006 Apr;29(2):145-53. doi: 10.1007/s10143-005-0001-9. Epub 2006 Jan 4.

Abstract

Hemangiopericytomas represent rare intracranial tumors that have a tendency to recur locally and have the unique characteristic of giving extracranial metastases. Our current communication reviews a series of patients diagnosed with hemangiopericytoma who were treated in our facility. Eleven patients with a mean age of 51.2 years underwent follow-up for a mean time of 7.1 years. Their neuroimaging preoperative evaluation included plain skull X-rays, head CT scans, brain MRI, angiograms, and (1)HMRS. Preoperative embolization of the tumor was employed in 6/11 patients. All patients underwent craniotomy for tumor resection and postoperative radiation treatment was employed on all but one. Grade I resection was accomplished in 6/11 (54.5%), grade III in 4/11 (36.4%), and grade IV in 1/11 (9.1%). Local recurrence was detected in 3/11 (27.3%) at a mean period of 5 (range 2-7.5) years. Extracranial metastatic disease was documented in 4/11 (36.4%) patients at a mean of 4.9 (range 2.5-7) years after the initial diagnosis. The GOS score was: 7/11 (63.6%) scored 5, while 4/11 (36.4%) died at a mean time of 5.5 (range 3-8) years after the initial diagnosis. Intracranial hemangiopericytomas management requires aggressive surgical resection, postoperative radiation treatment, and extensive follow-up to rule out local recurrences and delayed extracranial metastases.

MeSH terms

  • Adult
  • Aged
  • Biomarkers, Tumor / analysis
  • Diagnostic Imaging
  • Female
  • Follow-Up Studies
  • Glasgow Outcome Scale
  • Hemangiopericytoma / diagnosis
  • Hemangiopericytoma / pathology
  • Hemangiopericytoma / surgery*
  • Humans
  • Image Processing, Computer-Assisted
  • Liver Neoplasms / diagnosis
  • Liver Neoplasms / secondary
  • Lung Neoplasms / diagnosis
  • Lung Neoplasms / secondary
  • Magnetic Resonance Spectroscopy
  • Male
  • Meningeal Neoplasms / diagnosis
  • Meningeal Neoplasms / pathology
  • Meningeal Neoplasms / surgery*
  • Meninges / pathology
  • Meninges / surgery
  • Middle Aged
  • Neoplasm Recurrence, Local / diagnosis
  • Neoplasm Recurrence, Local / pathology
  • Postoperative Complications / diagnosis

Substances

  • Biomarkers, Tumor