Abstract
There is growing recognition of the association between the use of gadolinium-containing radiocontrast agents for magnetic resonance imaging and the serious dermal and systemic disease nephrogenic fibrosing dermopathy/nephrogenic systemic fibrosis (NFD/NSF). The pathogenesis of this entity remains unclear; however, our recent observations suggest a likely mechanism for the initial dermal manifestations of this gadolinium toxicity.
MeSH terms
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Acidosis / complications
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Aged
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Blood Vessels / chemistry
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Bone Marrow Cells / pathology
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Calcium Phosphates / analysis
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Contrast Media / adverse effects
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Contrast Media / analysis*
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Contrast Media / pharmacokinetics
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Cyclosporine / adverse effects
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Electron Probe Microanalysis
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Female
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Fibrosis
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Gadolinium / adverse effects
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Gadolinium / analysis*
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Gadolinium / pharmacokinetics
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Hepatitis C, Chronic / complications
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Hepatitis C, Chronic / surgery
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Humans
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Hypocalcemia / complications
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Kidney Failure, Chronic / chemically induced
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Kidney Failure, Chronic / complications
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Kidney Failure, Chronic / therapy
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Liver Failure / complications
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Liver Failure / surgery
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Magnetic Resonance Imaging
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Microscopy, Electron, Scanning
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Models, Biological
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Phosphates / blood
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Postoperative Complications / etiology
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Postoperative Complications / metabolism
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Postoperative Complications / pathology
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Renal Dialysis
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Skin / blood supply
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Skin / chemistry*
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Skin / pathology
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Skin Diseases / etiology
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Skin Diseases / metabolism*
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Skin Diseases / pathology
Substances
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Calcium Phosphates
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Contrast Media
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Phosphates
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Cyclosporine
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calcium phosphate
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Gadolinium