Abstract
Thin-section noncontrast CT (NCT) can detect thrombi in large arteries and can provide a measure of thrombus composition based on Hounsfield Units (HU). A study using polyethylene tubes as a model of intracranial arteries concluded that the HUs of platelet-rich thrombi are lower than those of erythrocyte-rich thrombi. Thrombus HUs were measured by NCT in 34 patients with acute ischemic stroke before thrombolysis. Thrombi with lower HU counts were resistant to thrombolytics.
MeSH terms
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Aged
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Aged, 80 and over
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Blood Platelets / diagnostic imaging
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Blood Platelets / pathology
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Brain Ischemia / diagnostic imaging*
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Brain Ischemia / drug therapy
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Brain Ischemia / physiopathology
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Cerebral Arteries / diagnostic imaging*
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Cerebral Arteries / drug effects
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Cerebral Arteries / physiopathology
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Drug Resistance / physiology
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Erythrocytes / diagnostic imaging
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Erythrocytes / pathology
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Female
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Fibrinolytic Agents / adverse effects
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Fibrinolytic Agents / pharmacology*
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Humans
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Intracranial Thrombosis / diagnostic imaging*
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Intracranial Thrombosis / drug therapy
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Intracranial Thrombosis / physiopathology
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Male
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Middle Aged
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Models, Biological
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Patient Selection
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Polyethylene
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Predictive Value of Tests
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Preoperative Care
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Stroke / diagnostic imaging*
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Stroke / drug therapy
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Stroke / physiopathology
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Tissue Plasminogen Activator / adverse effects
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Tissue Plasminogen Activator / pharmacology
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Tomography, X-Ray Computed / methods*
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Tomography, X-Ray Computed / standards
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Tomography, X-Ray Computed / trends
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Treatment Outcome
Substances
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Fibrinolytic Agents
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Polyethylene
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Tissue Plasminogen Activator