Abstract
The purpose of the study was to evaluate the usefulness of perfusion CT (pCT) in differentiating Alzheimer's disease (AD) from vascular dementia (VaD) and mixed dementia (MixD). pCT was performed in 41 patients (mean age, 68.3 years): 24 with AD, 8 with VaD, and 9 with MixD. Regional perfusion parameters (rCBF, rCBV, and rMTT) were calculated from 31 ROIs in the grey and white matter of the frontal and temporal lobes, basal ganglia, and internal capsules bilaterally. The obtained data for the subgroups of AD, VaD, and MixD patients were compared statistically.
Conclusions:
On the basis of rCBF and rCBV values, pCT may be a valuable method of distinguishing between AD and VaD but it seems to be of little significance in differentiating MixD from VaD and of no usefulness in distinguishing between AD and MixD.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Aged, 80 and over
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Alzheimer Disease / diagnostic imaging*
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Alzheimer Disease / pathology
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Alzheimer Disease / physiopathology
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Basal Ganglia / diagnostic imaging
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Basal Ganglia / pathology
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Basal Ganglia / physiopathology
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Brain / diagnostic imaging*
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Brain / pathology
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Brain / physiopathology
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Cerebral Arteries / pathology
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Cerebral Arteries / physiopathology
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Cerebrovascular Circulation / physiology
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Contrast Media / standards
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Dementia, Vascular / diagnostic imaging*
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Dementia, Vascular / pathology
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Dementia, Vascular / physiopathology
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Diagnosis, Differential
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Female
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Frontal Lobe / diagnostic imaging
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Frontal Lobe / pathology
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Frontal Lobe / physiopathology
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Humans
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Internal Capsule / diagnostic imaging
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Internal Capsule / pathology
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Internal Capsule / physiopathology
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Iodine Radioisotopes
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Male
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Middle Aged
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Nerve Fibers, Myelinated / pathology
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Predictive Value of Tests
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Temporal Lobe / diagnostic imaging
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Temporal Lobe / pathology
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Temporal Lobe / physiopathology
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Tomography, X-Ray Computed / methods*
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Tomography, X-Ray Computed / standards
Substances
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Contrast Media
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Iodine Radioisotopes