Automated MR spectroscopy of intra- and extraventricular neurocytomas

Magn Reson Med Sci. 2007;6(2):75-81. doi: 10.2463/mrms.6.75.

Abstract

Purpose: We evaluated the automated magnetic resonance spectroscopic (MRS) characteristics of intra- and extraventricular neurocytomas.

Materials and methods: One extra- and 4 intraventricular neurocytomas were studied. Automated single-voxel proton MRS was performed with a 1.5 T MR scanner. The results of 6 total automated MR spectra were analyzed for each tumor.

Results: Lactate resonance was detected as a doublet in 3 MR spectra of 2 intraventricular neurocytomas. A peak corresponding to N-acetylaspartate (NAA) was small in 5 MR spectra of 4 intraventricular neurocytomas. Creatine (Cr) resonance was detected in all 6 MR spectra. Prominent choline (Cho) resonance was found in all 6 MR spectra. The myoinositol (MI) and/or glycine (Gly) peaks were large in 3 MR spectra of 2 intraventricular neurocytomas.

Conclusion: The presence of the NAA signal and high MI and/or Gly signals may be characteristic features of intraventricular neurocytomas. A combination of prominent Cho resonance and detectable Cr resonance is a common feature of both intra- and extraventricular neurocytomas.

Publication types

  • Evaluation Study

MeSH terms

  • Adolescent
  • Adult
  • Aspartic Acid / analogs & derivatives
  • Aspartic Acid / metabolism
  • Brain / pathology
  • Cerebral Ventricle Neoplasms / diagnosis*
  • Cerebral Ventricle Neoplasms / metabolism
  • Cerebral Ventricles / pathology*
  • Choline / metabolism
  • Contrast Media / administration & dosage
  • Creatine / metabolism
  • Female
  • Gadolinium DTPA
  • Glycine / metabolism
  • Humans
  • Image Enhancement / methods
  • Image Processing, Computer-Assisted / methods
  • Inositol / metabolism
  • Magnetic Resonance Spectroscopy / methods*
  • Male
  • Neurocytoma / diagnosis*
  • Neurocytoma / metabolism
  • Reproducibility of Results

Substances

  • Contrast Media
  • Aspartic Acid
  • Inositol
  • N-acetylaspartate
  • Gadolinium DTPA
  • Creatine
  • Choline
  • Glycine