Sculptra is a biocompatible, resorbable injectable filler composed of poly-L-lactic acid (PLLA). It falls in the class of a stimulatory filler that creates its effect through encouraging neocollagenesis when injected. As it differs from traditional, static fillers such as hyaluronic acid and collagen, it requires a special understanding of how it works, where it can be used, and how it should be injected. The goal of this article is to review the nature of stimulatory volume replacement with a focus on PLLA and its unique considerations. Both the natural method of volume restoration and the persistence of results of up to 2 to 3 years make this product one worthy of inclusion in the first line of tools for cosmetic rejuvenation as well as for reconstructive soft tissue deficits and lipoatrophy.