Focal cerebral dysfunction in developmental learning disabilities

Lancet. 1990 Jan 6;335(8680):8-11. doi: 10.1016/0140-6736(90)90136-s.

Abstract

In 24 children with developmental learning disabilities and 15 age-matched controls regional cerebral activity was studied with xenon-133 single photon emission tomography. In the 9 children with pure attention deficit and hyperactivity disorder (ADHD), the distribution of regional cerebral activity was abnormal--low in striatal and posterior periventricular regions and high in occipital regions. Low activity in striatal and posterior periventricular areas was also seen in the 8 children with ADHD in combination with phonologic-syntactic dysphasia. 7 children with dysphasia, but without hyperactive behaviour, had low cerebral activity in left temporofrontal regions.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Attention Deficit Disorder with Hyperactivity / diagnostic imaging
  • Attention Deficit Disorder with Hyperactivity / physiopathology*
  • Caudate Nucleus / blood supply
  • Caudate Nucleus / diagnostic imaging
  • Cerebrovascular Circulation*
  • Child
  • Color
  • Evaluation Studies as Topic
  • Female
  • Frontal Lobe / blood supply
  • Frontal Lobe / diagnostic imaging
  • Humans
  • Language Disorders / diagnostic imaging
  • Language Disorders / physiopathology*
  • Learning Disabilities / physiopathology
  • Male
  • Occipital Lobe / blood supply
  • Occipital Lobe / diagnostic imaging
  • Temporal Lobe / blood supply
  • Temporal Lobe / diagnostic imaging
  • Tomography, Emission-Computed, Single-Photon
  • Xenon Radioisotopes

Substances

  • Xenon Radioisotopes