Abstract
Mutations at the mouse dwarf locus (dw) interrupt the normal development of the anterior pituitary gland, resulting in the loss of expression of growth hormone, prolactin and thyroid-stimulating hormone, and hypoplasia of their respective cell types. Disruptions in the gene encoding the POU-domain transcription factor, Pit-1, occur in both characterized alleles of the dwarf locus. The data indicate that Pit-1 is necessary for the specification of the phenotype of three cell types in the anterior pituitary, and directly link a transcription factor to commitment and progression events in mammalian organogenesis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Chromosome Mapping
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DNA-Binding Proteins / genetics*
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Dwarfism, Pituitary / genetics*
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Gene Expression*
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Genes, Homeobox / genetics
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Growth Hormone / genetics
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Mice
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Mice, Inbred C3H
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Mice, Inbred Strains
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Molecular Sequence Data
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Mutation*
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Nucleic Acid Hybridization
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Phenotype
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Pituitary Gland, Anterior / cytology
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Pituitary Gland, Anterior / growth & development
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Pituitary Gland, Anterior / metabolism*
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Polymorphism, Restriction Fragment Length
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Prolactin / genetics
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Restriction Mapping
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Transcription Factor Pit-1
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Transcription Factors / genetics*
Substances
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DNA-Binding Proteins
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Pit1 protein, mouse
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Transcription Factor Pit-1
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Transcription Factors
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Prolactin
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Growth Hormone