Acute necrotizing encephalopathy secondary to diphtheria, tetanus toxoid and whole-cell pertussis vaccination: diffusion-weighted imaging and proton MR spectroscopy findings

Hale Aydin; Esra Ozgul; Ahmet Muhtesem Agildere

doi:10.1007/s00247-009-1498-9

Acute necrotizing encephalopathy secondary to diphtheria, tetanus toxoid and whole-cell pertussis vaccination: diffusion-weighted imaging and proton MR spectroscopy findings

Pediatr Radiol. 2010 Jul;40(7):1281-4. doi: 10.1007/s00247-009-1498-9. Epub 2010 Jan 30.

Authors

Hale Aydin¹, Esra Ozgul, Ahmet Muhtesem Agildere

Affiliation

¹ Department of Radiology, Baskent University Hospital, Ziya Gokalp, Cad 10, sok No: 45 Bahcelievler, Ankara 06610, Turkey. halemaydin@gmail.com

PMID: 20119724
DOI: 10.1007/s00247-009-1498-9

Abstract

We present a previously healthy 6-month-old boy who was admitted to our hospital with lethargy, hypotonia and focal clonic seizures 6 days following diptheria, tetanus toxoid and whole-cell pertussis vaccination. A diagnosis of acute necrotising encephalopathy was made with the aid of MRI, including diffusion-weighted imaging and proton MR spectroscopy.

Publication types

Case Reports

MeSH terms

Brain / drug effects
Brain / pathology*
Diffusion Magnetic Resonance Imaging / methods*
Diphtheria / complications*
Humans
Infant
Leukoencephalitis, Acute Hemorrhagic / chemically induced*
Leukoencephalitis, Acute Hemorrhagic / diagnosis*
Magnetic Resonance Spectroscopy / methods*
Male
Pertussis Vaccine / adverse effects*
Tetanus Toxin
Tetanus Toxoid / adverse effects*

Substances

Pertussis Vaccine
Tetanus Toxin
Tetanus Toxoid