Selecting appropriate voxel-based methods for neuroimaging studies

David F Abbott; Gaby S Pell; Heath R Pardoe; Graeme D Jackson

doi:10.1016/j.neuroimage.2011.06.083

Selecting appropriate voxel-based methods for neuroimaging studies

Neuroimage. 2012 Jan 16;59(2):885-6. doi: 10.1016/j.neuroimage.2011.06.083. Epub 2011 Jul 6.

Authors

David F Abbott¹, Gaby S Pell, Heath R Pardoe, Graeme D Jackson

Affiliation

¹ Florey Neuroscience Institutes, Melbourne Brain Centre, Austin Hospital, Victoria, Australia. BRI@brain.org.au

PMID: 21763436
DOI: 10.1016/j.neuroimage.2011.06.083

Abstract

We highlight a fundamental difference between voxel-based methods that interrogate signal intensity directly and those that interrogate morphometric features; we discuss how signal intensity changes might erroneously affect morphometric measures, and we provide some guidance for selection of appropriate methods to address particular hyphotheses. Our discussion is motivated by a recent application of voxel-based morphometry methods to T2-weighted images (T2-Voxel Based Morphometry; T2-VBM). In this context we discuss alternative approaches including Voxel-Based T2-Relaxometry (VBR) and Voxel Based Iterative Sensitivity analysis of T2-Weighted Images (VBIS-T2).

Publication types

Comment

MeSH terms

Alzheimer Disease / pathology*
Brain / pathology*
Female
Humans
Image Interpretation, Computer-Assisted / methods*
Imaging, Three-Dimensional / methods*
Magnetic Resonance Imaging / methods*
Male