Reversible and irreversible cranial MRI findings associated with status epilepticus

A M Cartagena; G B Young; D H Lee; S M Mirsattari

doi:10.1016/j.yebeh.2014.02.003

Reversible and irreversible cranial MRI findings associated with status epilepticus

Epilepsy Behav. 2014 Apr:33:24-30. doi: 10.1016/j.yebeh.2014.02.003. Epub 2014 Mar 12.

Authors

A M Cartagena¹, G B Young², D H Lee³, S M Mirsattari⁴

Affiliations

¹ Department of Neurology/Clinical Neurophysiolgy, Detroit Medical Center, Wayne State University, Detroit, Michigan, USA; Department of Clinical Neurological Sciences, Western University, London, Canada. Electronic address: acartage@uwo.ca.
² Department of Clinical Neurological Sciences, Western University, London, Canada.
³ Department of Clinical Neurological Sciences, Western University, London, Canada; Department of Medical Imaging, Western University, London, Canada.
⁴ Department of Clinical Neurological Sciences, Western University, London, Canada; Department of Medical Imaging, Western University, London, Canada; Department of Medical Biophysics, Western University, London, Canada; Department of Psychology, Western University, London, Canada.

PMID: 24614522
DOI: 10.1016/j.yebeh.2014.02.003

Abstract

Objective: There is limited information on neuroimaging changes in status epilepticus (SE). The objective of this study was to characterize the abnormalities associated with SE in cranial MRI of patients with SE.

Methods: A retrospective review of our records from 2001 to 2010 identified 203 patients with SE. Magnetic resonance imaging (MRI) changes considered were not attributable to any neurological disorder.

Results: Ten patients who met the inclusion criteria were found to have significant abnormalities. Magnetic resonance imaging findings included increased T2 signal changes in the gray and/or white matter with corresponding diffusion-weighted imaging (DWI) abnormalities (n=9). Apparent diffusion coefficient (ADC) values were both reduced (n=3) and increased (n=3). Other findings included changes affecting one hemisphere, a perilesional and homologous region, hippocampal changes, and findings in the thalamus, basal ganglia, brain stem, and cerebellum.

Conclusions: Magnetic resonance imaging changes were diffuse. Notably, MRI changes were found to involve the brain stem, cerebellum, basal ganglia, and thalamus. Magnetic resonance imaging changes in the latter areas have not been previously well described. In addition, MRI changes tended to evolve after 1week; therefore, serial MRI is recommended in order to follow and highlight the MRI changes related to the neuroanatomic involvement seen in status epilepticus.

Keywords: Epilepsy; MRI; Status epilepticus.

MeSH terms

Adult
Brain / pathology*
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Retrospective Studies
Status Epilepticus / pathology*
Young Adult