We present a rare case of a variant middle meningeal artery (MMA) originating from the ophthalmic artery. During cadaveric dissection of the cranial base of an adult female, it was noted that the foramen spinosum was absent unilaterally. After identifying the MMA, its origin was traced back to the ophthalmic artery within the orbit. Although exceedingly rare, a variant MMA originating from the ophthalmic artery should be kept in mind by surgeons during skull base procedures in order to avoid unwanted complications including potential retrograde thrombosis of the ophthalmic artery with MMA manipulation or coagulation.