Detection of small brain metastases at 3 T: comparing the diagnostic performances of contrast-enhanced T1-weighted SPACE, MPRAGE, and 2D FLASH imaging

Hyo-Sung Kwak; Seungbae Hwang; Gyung-Ho Chung; Ji-Soo Song; Eun-Jung Choi

doi:10.1016/j.clinimag.2015.02.010

Detection of small brain metastases at 3 T: comparing the diagnostic performances of contrast-enhanced T1-weighted SPACE, MPRAGE, and 2D FLASH imaging

Clin Imaging. 2015 Jul-Aug;39(4):571-5. doi: 10.1016/j.clinimag.2015.02.010. Epub 2015 Feb 26.

Authors

Hyo-Sung Kwak¹, Seungbae Hwang², Gyung-Ho Chung¹, Ji-Soo Song³, Eun-Jung Choi³

Affiliations

¹ Department of Radiology, Chonbuk National University Medical School and Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju-si, Jeollabuk-do 561-712, Korea; Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital.
² Department of Radiology, Chonbuk National University Medical School and Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju-si, Jeollabuk-do 561-712, Korea; Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital. Electronic address: sbh1010@jbnu.ac.kr.
³ Department of Radiology, Chonbuk National University Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju-si, Jeollabuk-do 561-712, Korea.

PMID: 25770904
DOI: 10.1016/j.clinimag.2015.02.010

Abstract

The aim of this study was to compare the diagnostic performance of contrast-enhanced T1-weighted sampling perfection with application-optimized contrasts using different flip angle evolutions (SPACE), magnetization-prepared rapid gradient-echo (MPRAGE), and two-dimensional (2D) fast low angle shot (FLASH) for the detection of small brain metastases. Twelve patients who had brain metastases less than 10 mm in diameter were enrolled. The diagnostic performance was evaluated using alternative free-response receiver operating characteristic analysis. Sensitivity and positive predictive value were also calculated. The mean Az and sensitivities of SPACE for all observers were significantly higher than those of MPRAGE and 2D FLASH.

Keywords: 3 Tesla; Brain; Magnetic resonance imaging; Neoplasm metastasis; SPACE.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Brain / pathology*
Brain Neoplasms / secondary*
Breast Neoplasms / pathology*
Female
Humans
Image Enhancement / methods*
Imaging, Three-Dimensional / methods*
Lung Neoplasms / pathology*
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Sensitivity and Specificity