Histopathology of Spindle Cell Vascular Tumors

Zlatko Marušić; Steven D Billings

doi:10.1016/j.path.2017.01.006

Histopathology of Spindle Cell Vascular Tumors

Surg Pathol Clin. 2017 Jun;10(2):345-366. doi: 10.1016/j.path.2017.01.006. Epub 2017 Mar 31.

Authors

Zlatko Marušić¹, Steven D Billings²

Affiliations

¹ Department of Pathology, University Hospital Center Zagreb, Kišpatićeva 12, Zagreb 10 000, Croatia.
² Department of Pathology, Cleveland Clinic, 9500 Euclid Avenue, L25, Cleveland, OH 44195, USA. Electronic address: billins@ccf.org.

PMID: 28477885
DOI: 10.1016/j.path.2017.01.006

Abstract

Vascular tumors with a spindled morphology represent a diagnostic challenge in soft tissue pathology. It may be difficult to distinguish certain benign entities in this category from spindled vascular tumors of intermediate malignancy or even spindled variants of angiosarcoma. This article focuses on vascular tumors characterized by a predominantly spindled morphology, including spindle cell hemangioma, acquired tufted angioma (angioblastoma of Nakagawa), kaposiform hemangioendothelioma, Kaposi sarcoma, and spindle cell variants of angiosarcoma.

Keywords: Acquired tufted angioma; Angioblastoma of Nakagawa; Angiosarcoma; Kaposi sarcoma; Kaposiform hemangioendothelioma; Spindle cell hemangioma.

Publication types

Review

MeSH terms

Diagnosis, Differential
Hemangioendothelioma / pathology*
Hemangioma / pathology*
Hemangiosarcoma / pathology*
Humans
Neoplasms, Vascular Tissue / pathology*
Skin Neoplasms / blood supply
Skin Neoplasms / pathology*