Gadolinium leakage in ocular structures in optic neuritis

Alex Förster; Johannes Böhme; Christoph Groden; Holger Wenz

doi:10.1016/j.jocn.2019.05.050

Gadolinium leakage in ocular structures in optic neuritis

J Clin Neurosci. 2019 Oct:68:268-270. doi: 10.1016/j.jocn.2019.05.050. Epub 2019 Jun 14.

Authors

Alex Förster¹, Johannes Böhme², Christoph Groden³, Holger Wenz⁴

Affiliations

¹ Department of Neuroradiology, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address: alex.foerster@umm.de.
² Department of Neuroradiology, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address: johannes.boehme@umm.de.
³ Department of Neuroradiology, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address: christoph.groden@umm.de.
⁴ Department of Neuroradiology, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address: holger.wenz@umm.de.

PMID: 31204221
DOI: 10.1016/j.jocn.2019.05.050

Abstract

Background: We investigated the frequency of blood-retina barrier impairment in optic neuritis (ON) using gadolinium leakage in ocular structures (GLOS), a novel imaging marker on contrast enhanced fluid attenuated inversion recovery images (FLAIR).

Methods: In 12 patients with acute ON who underwent repeated MRI the presence of GLOS was noted on contrast-enhanced FLAIR.

Results: Bilateral GLOS was observed in 4 (33.3%): in 3 symmetrical, and in 1 asymmetrical. In the latter GLOS was ipsilateral to the ON.

Conclusions: GLOS may be observed frequently in ON. Asymmetrical GLOS may be caused by a more local effect of ON.

Keywords: Contrast-enhanced; FLAIR; GLOS; Gadolinium leakage in ocular structures; Optic neuritis.

MeSH terms

Adult
Aged
Capillary Permeability
Contrast Media
Female
Gadolinium*
Humans
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Optic Neuritis / diagnostic imaging*
Optic Neuritis / pathology

Substances

Contrast Media
Gadolinium